| LIAO An-yan,WANGJun-jie,ZHAO Yong,et al.The inhabitation effect of 125I seed irradiation on prostate cancer cell[J].Chinese Journal of Radiological Medicine and Protection,2007,27(3):226-228 |
| The inhabitation effect of 125I seed irradiation on prostate cancer cell |
| Received:January 30, 2007 |
| DOI： |
| KeyWords:125I seeds Prostate cancer cell Cell proliferation Cell cycle |
| FundProject:国家自然科学基金资助项目(30572137) |
| Author Name | Affiliation | E-mail | | LIAO An-yan | Cancer Center,Peking University Third Hospital,Beijing 100083,China | | | WANGJun-jie | Cancer Center,Peking University Third Hospital,Beijing 100083,China | junjiew-@263.net | | ZHAO Yong | 中国科学院动物研究所生物膜国家重点实验室 | | | 王济东 | Cancer Center,Peking University Third Hospital,Beijing 100083,China | | | 庄洪卿 | Cancer Center,Peking University Third Hospital,Beijing 100083,China | |
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| Abstract:: |
| Objective To study the effect on prostate cancer cell proliferation and cell cycle treated by continuous low dose rate 125I irradiation.Methods PC3 cell was irradiated with 125I (2.77 cGy/h) and 60Co(2.215 Gy/min) at various doses.The cellular proliferation,vitality and cell surviving rate were evaluated by cytometric methods,typan_blue stain and the colony_forming assay after radiation.The cell cycle distribution was investigated by FCM. Results\ The death rate of PC3 cell exposed to 125I was higher than that exposed to 60Co gamma rays with the increase of the irradiation dose.The parameters of radiobiology of PC3 irradiated by 125I seeds were:D0=2.243,Dq=0.87,N=1.618,SF2=0.5 whereas the parameters of 60Co were:D0=2.824,Dq=1.08,N=1.587,SF2=0.7.The RBE for 125I compared with 60Co gamma rays is 1.4.The cell cycle distribution after 4 Gy 125I or 60Co irradiation was similar,with increasing in the proportion of cells in G2 phase after 24 h.Conclusions 125I irradiation could inhibit the proliferation of PC3 and induced G2 phase arrest. |
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