| WU Ning,CHEN Guang-wei,LIU Yong-zhe,et al.Effect of low dose whole-body X-irradiation on the efficacy of pEgr-IL18-B7.1 gene-radiotherapy[J].Chinese Journal of Radiological Medicine and Protection,2007,27(3):223-225 |
| Effect of low dose whole-body X-irradiation on the efficacy of pEgr-IL18-B7.1 gene-radiotherapy |
| Received:April 17, 2006 |
| DOI： |
| KeyWords:Low dose X-rays Recombinant plasmid pEgr-IL18-B7.1 Gene-radiotherapy Lewis lung carcinoma |
| FundProject:国家自然科学基金资助项目(30100033) |
| Author Name | Affiliation | | WU Ning | Key Laboratory of Radiobiology,Ministry of Health(Jilin University),Changchun 130021,China | | CHEN Guang-wei | 吉林省卫生厅卫生监督所 | | LIU Yong-zhe | Key Laboratory of Radiobiology,Ministry of Health(Jilin University),Changchun 130021,China | | 金顺子 | Key Laboratory of Radiobiology,Ministry of Health(Jilin University),Changchun 130021,China | | 刘树铮 | Key Laboratory of Radiobiology,Ministry of Health(Jilin University),Changchun 130021,China |
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| Abstract:: |
| Objective To observe the therapeutic effect of whole-body irradiation with low dose X-rays in mice bearing Lewis lung carcinoma under recombinant plasmid pEgr-IL18-B7.1 gene-radiotherapy. Methods The pEgr-IL18-B7.1 recombinant plasmids mediated by polyethylenimine were injected locally into tumors of the mice with gene-radiotherapy,and then the tumors received different therapeutic regimens containing local X-irradiation with 2 Gy and whole-body X-irradiation with 0.075 Gy, respectively. The anti-tumor effects of low dose X-rays in optimizing the protocol of pEgr_IL18_B7.1 gene-radiotherapy on the tumor-bearing mice were observed.Results As compared with repeated high dose local X-irradiation alone,single high dose local X-irradiation in combination with repeated low dose of whole-body X-irradiation showed more significant inhibition of tumor growth under pEgr-IL18-B7.1 gene-radiotherapy.Conclusions Low dose whole-body X-irradiation superimposed upon a local high dose could significantly enhance the anti-tumor effect in the protocol of pEgr-IL18-B7.1 gene-radiotherapy. |
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