| HUANG Yi,HUANG Yi,RAN Wei-qiang,et al.Rectal complications of 125I interstitial brachytherapy for prostate cancer under transrectal ultrasonography guidance\[J].Chinese Journal of Radiological Medicine and Protection,2007,27(2):172-174 |
| Rectal complications of 125I interstitial brachytherapy for prostate cancer under transrectal ultrasonography guidance\ |
| Received:March 17, 2006 |
| DOI： |
| KeyWords:125I seed Prostate carcinmoma Brachytherapy Transrectal ultrasonography Rectum morbidity |
| FundProject: |
| Author Name | Affiliation | | HUANG Yi | The 3 Hospital of Peking University, Beijing 100083, China | | HUANG Yi | The 3 Hospital of Peking University, Beijing 100083, China | | RAN Wei-qiang | The 3 Hospital of Peking University, Beijing 100083, China | | 李金娜 | The 3 Hospital of Peking University, Beijing 100083, China | | 姜伟娟 | The 3 Hospital of Peking University, Beijing 100083, China | | 刘江平 | The 3 Hospital of Peking University, Beijing 100083, China | | 姜玉良 | The 3 Hospital of Peking University, Beijing 100083, China | | 田素青 | The 3 Hospital of Peking University, Beijing 100083, China | | 江萍 | The 3 Hospital of Peking University, Beijing 100083, China |
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| Abstract:: |
| Objective To investigate the rectal complications of ultrasound-guided transperineal interstitial permanent prostate brachytherapy(TIPPB)in prostate cancer. Methods 80 patients treated with transperineal 125I seed brachytherapy guided by utrasound,including 68 patients treated with seed implantation and 12 patients treated with seed plus external beam radiotherapy(EBRT). The matched peripheral doses (MPD)of monotherapy and conbined with EBRT group were 140-160 Gy and 90-110 Gy, respectively.The EBRT doses were 40-50 Gy/4-5 weeks,20 Gy/f,5 f/week,the interval between seed implantation and EBRT was 4 weeks. The activity of each seed ranged from 0.35 to 0.50 mCi,the number of seeds was from 19 to 100.The pelvic CT scan was given one month post-implantaion and undertook quality evaluation. Results 68 patients with monotherapy of 125I seed implantation and 12 patients with 125I seed implantation combined with EBRT. The incidence of side effect of Grades Ⅰ, Ⅱ, Ⅲ and Ⅳ rectum morbidity after 125I seed implantation were 7.3%,4.4%,2.9% and 1.5%, respectively. Grades I and Ⅱ rectum morbidity of patients treated with seed implantation plus EBRT was 10% and 10%, respectively, with no side effects in grades Ⅲ and Ⅳ.The median time for rectum side effect was 12 months(1-16). Conclusions Transperineal interstitial permanent brachytherapy is a tolerable and acceptable treatment option as used alone and combined with EBRT. |
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