| YU Guang-wei,MAO Xin-jian.Dosimetry evaluation and feasibility of intensity-modulated radiotherapy for non-small-cell lung cancer[J].Chinese Journal of Radiological Medicine and Protection,2007,27(2):167-169 |
| Dosimetry evaluation and feasibility of intensity-modulated radiotherapy for non-small-cell lung cancer |
| Received:March 22, 2006 |
| DOI： |
| KeyWords:Non-small-cell cancer Three-dimensional conformal radiotherapy Intensity-modulated radiotherapy |
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| Abstract:: |
| Objective To investigate the feasibility of intensity-modulated radiotherapy for non-smallcell lung cancer with respect to target-dose conformity & heterogeneity and normal tissue sparing. Methods In order to compare intensity-modulated and three-dimensional conformal radiotherapy of twenty non-small-cell lung cancer patients with stage Ⅰ-Ⅳ, retrospective treatment planning study was performed. The two types of plans were designed to deliver 64 Gy to 95% of the planning target volume and to minimize the volume of normal lung, esophagus, heart and spinal cord irradiated above their tolerance doses. All plans were compared according to the planning target volume coverage, dose-volume histogram and other dosimetric parameters of normal tissues. Results Commpared with three-dimensional conformal radiotherapy, the intensity-modulated plan improved conformity without significantly sacrificing the heterogeneity with regard to planning target volume coverage. The V20 and mean dose lung of were reduced with a median reduction of 11% and 2 Gy. Conclusions It is indicated that intensity-modulated radiotherapy may be more applicable for non-small-cell lung cancer than three-dimensional conformal radiotherapy. |
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