| ZHU Shu-chai,SHEN Wen-bin,LI Ren,et al.Radiation-induced pneumonitis in three-dimensional conformal radiotherapy for oesophageal carcinoma[J].Chinese Journal of Radiological Medicine and Protection,2007,27(2):161-163 |
| Radiation-induced pneumonitis in three-dimensional conformal radiotherapy for oesophageal carcinoma |
| Received:April 04, 2006 |
| DOI： |
| KeyWords:Esophageal carcinoma Radiotherapy Three-dimensional conformal radiotherapy Radiation-induced pneumonitis |
| FundProject:教育部高等学校青年教师教学科研奖励计划基金资助项目(2001125);河北省自然科学基金资助项目(C2005800802) |
| Author Name | Affiliation | | ZHU Shu-chai | Department of Radiation Oncology, The Forth Hospital, Hebei Medical University, Shijiazhuang 050011, China | | SHEN Wen-bin | Department of Radiation Oncology, The Forth Hospital, Hebei Medical University, Shijiazhuang 050011, China | | LI Ren | Department of Radiation Oncology, The Forth Hospital, Hebei Medical University, Shijiazhuang 050011, China | | 王玉祥 | Department of Radiation Oncology, The Forth Hospital, Hebei Medical University, Shijiazhuang 050011, China | | 苏景伟 | Department of Radiation Oncology, The Forth Hospital, Hebei Medical University, Shijiazhuang 050011, China | | 李娟 | Department of Radiation Oncology, The Forth Hospital, Hebei Medical University, Shijiazhuang 050011, China |
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| Abstract:: |
| Objective To evaluate the clinical factors and physical parameters related to radiation-induced pneumonitis in oesophageal carcinoma treated with three-dimensional conformal radiotherapy (3DCRT). Methods From October 2000 to December 2003, 55 esophageal carcinoma patients were retrospectively reviewed with clinical factors and physical parameters in relation to radiation-induced pneumonitis. Logistic regression model was used to test their relativities. Results According to the RTOG criteria, pneumonitis was observed in 12 patients, the rate of incidence 22%, with 9 in grade Ⅱ, 3 in grade Ⅲ. Secondary-course radiotherapy, total dose, the late-course irradiation beams, total irradiation beams, lungs V10, lungs V15, lungs V20, lungs V25 and lungs Dmean, and oesophageal GTVV50 were significantly correlated with radiation-indueed pneumonitis. Multilogistic regression analysis showed that secondary-course radiotherapy, the late-course irradiation beams and lungs V25 were the independent inducing factors for pneumonitis, Radiation-induced pneumonitis had no significant effect on the survival of esophageal carcinoma. Conclusions There are no significantly difference in the radiation-induced pneumonitis with the two model of total-course 3D-CRT and the secondary-course 3D-CRT. Secondary-course radiotherapy. the late-course irradiation beams and lungs V25 are significantly associated with the pneumonitis in oesophageal carcinoma patients treated with 3D-CRT. |
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