| YAO Bo,JIANG Ben-rong,QIU Li-juan,et al.Biological dose estimation and cytogenetic follow-up observation for a patient with subacute radiation sickness \[J].Chinese Journal of Radiological Medicine and Protection,2007,27(2):154-156 |
| Biological dose estimation and cytogenetic follow-up observation for a patient with subacute radiation sickness \ |
| Received:March 06, 2006 |
| DOI： |
| KeyWords:Subacute radiation sickness Biological dose estimation Chromosome aberration Micronuclei |
| FundProject: |
| Author Name | Affiliation | | YAO Bo | Department of Radiation Medicine & Clinical Hematology, Beijing 307 Hospital, Beijing 100071, China | | JIANG Ben-rong | Department of Radiation Medicine & Clinical Hematology, Beijing 307 Hospital, Beijing 100071, China | | QIU Li-juan | Department of Radiation Medicine & Clinical Hematology, Beijing 307 Hospital, Beijing 100071, China | | 贾蜀琼 | Department of Radiation Medicine & Clinical Hematology, Beijing 307 Hospital, Beijing 100071, China | | 满秋红 | Department of Radiation Medicine & Clinical Hematology, Beijing 307 Hospital, Beijing 100071, China | | 艾辉胜 | Department of Radiation Medicine & Clinical Hematology, Beijing 307 Hospital, Beijing 100071, China |
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| Abstract:: |
| Objective To conduct the biological dose estimation and cytogenetic observation for the patient with subacute radiation sickness in a 192Ir source radiation accident. Methods Conventional chromosome aberration analysis and micronucleus assay in peripheral blood lymphocytes were performed,and the accumulated dose was estimated by G function according to the frequencies of dicentric and ring on the patient. Results The estimated doses were close to those values estimated by physical method, in accordance with the appearance expression of clinical symptoms. At 1.5 and 2.5 years after the accident, clear decrease were observed in dicentric chromosomes but not in acentric fragments and micronuclei. Conclusions The estimation of accumulated dose by G function can reflect the real degree of radiation damage. The decreased rate of chromosome aberration and micronucleus in the patient with subacute radiation sickness might be slower than those with acute radiation sickness. |
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