| CHEN Chuang-zhen,LI De-rui,LIN Ying-cheng,et al.Arsenic trioxide enhances radiosensitivity of nasopharyngeal carcinoma: preliminary results of phaseⅡ clinical trial\[J].Chinese Journal of Radiological Medicine and Protection,2007,27(2):149-151 |
| Arsenic trioxide enhances radiosensitivity of nasopharyngeal carcinoma: preliminary results of phaseⅡ clinical trial\ |
| Received:May 16, 2006 |
| DOI： |
| KeyWords:Nasopharyngeal neoplasm Arsenic trioxide Radiotherapy Radiosensitizer |
| FundProject:国家中医药管理局中医药科学技术研究专项基金资助项目(04- 05LL10);广东省科技攻关基金资助项目(2004B30301014);广东省中医药管理局科研立项资助项目(102053) |
| Author Name | Affiliation | E-mail | | CHEN Chuang-zhen | Department of Radiotherapy, Cancer Hospital, Shantou University Medical College, Shantou 510031, China | | | LI De-rui | Department of Radiotherapy, Cancer Hospital, Shantou University Medical College, Shantou 510031, China | derui-li@yahoo.com.cn | | LIN Ying-cheng | Department of Radiotherapy, Cancer Hospital, Shantou University Medical College, Shantou 510031, China | | | 陈志坚 | Department of Radiotherapy, Cancer Hospital, Shantou University Medical College, Shantou 510031, China | | | 周明镇 | Department of Radiotherapy, Cancer Hospital, Shantou University Medical College, Shantou 510031, China | | | 郭隆佳 | Department of Radiotherapy, Cancer Hospital, Shantou University Medical College, Shantou 510031, China | | | 谢良喜 | Department of Radiotherapy, Cancer Hospital, Shantou University Medical College, Shantou 510031, China | |
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| Abstract:: |
| Objective To evaluate the radiosensitizing effect of arsenic trioxide (ATO) on nasopharyngeal carcinoma(NPC). Methods Sixty-one patients with NPC of T1-4N0-1M0 were randomized into two groups: conventional fractionation radiotherapy (CFR) group and CFR+ ATO group. 29 patients in CFR group were irradiated by 2.0 Gy/fraction, 5 times a week, with total dose of 70-80 Gy. 32 cases in CFR+ATO group received radiotherapy (RT) the same as the CFR group, but daily 10 mg ATO was added 2 days before RT and then concurrent with RT for 4 weeks. The regressions of nasopharyngeal lesions and cervical lymph nodes and acute toxicities were compared between two groups. Results When irradiation dose reached 40 Gy, the completely regression rates of nasopharyngeal lesion were 17.24%(5/29)in CFR group and 53.13%(17/32)in CFR+ ATO group, respectively. The difference was statistically significant (χ2＝8.495, P=0.004). The differences of side effects between two groups were not statistically significant except of nausea and vomiting and granulocytopenia, which were more frequent in CFR+ATO group. Most patients experienced Grade 1 to 2 acute toxicities in both groups. No Grade 4 toxicity was observed in all patients. Conclusions ATO enhances radiosensitivity of nasopharyngeal carcinoma without severe side effects. |
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