| ZHANG Yin-yin,TANG Ya-mei,CHEN Zheng,et al.Study on chromosome aberration frequency in prediction of radiation encephalopathy after radiotherapy for nasopharyngeal cancer[J].Chinese Journal of Radiological Medicine and Protection,2007,27(2):142-144 |
| Study on chromosome aberration frequency in prediction of radiation encephalopathy after radiotherapy for nasopharyngeal cancer |
| Received:February 05, 2006 |
| DOI： |
| KeyWords:Nasopharyngeal cancer Radiation encephalopathy Chromosome aberration |
| FundProject:国家自然科学基金资助项目(30600164) |
| Author Name | Affiliation | E-mail | | ZHANG Yin-yin | Department of Internal Medicine, The Second Affiliated Hospital, Sun Yat-sen University, Guangzhou 510120, China | | | TANG Ya-mei | Department of Internal Medicine, The Second Affiliated Hospital, Sun Yat-sen University, Guangzhou 510120, China | yameitang@hotmail.com | | CHEN Zheng | 中山大学医学院遗传教研室 | | | 郭灵 | 中山大学附属肿瘤医院鼻咽科 | | | 邢诒刚 | Department of Internal Medicine, The Second Affiliated Hospital, Sun Yat-sen University, Guangzhou 510120, China | |
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| Abstract:: |
| Objective To investigate the correlation between the chromosome aberration frequency and radiation encephalopathy(REP), and to evaluate the feasibility of the index in prediction the onset and severity of REP. Methods The metaphase chromosome method was used to test chromosomal aberration frequencies of 17 patients with REP and 17 patients without REP after radiotherapy for nasopharyngeal cancer. The correlation between chromosomal aberration frequencies and REP was analyzed. Results Radiation induced chromosome aberration alone, and the accumulation effect of it and spontaneous aberration have correlation to the onset and severity of REP, in which the latter is more serious. Conclusions Chromosome aberration has the potential to be used as in prediction of REP. |
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