| LIU Yun-lin,ZHOU Hai-hong,LI Xi-ming.Quantitative analysis of the effect of basic fibroblast growth factor on radiation induced blood brain barrier disruption[J].Chinese Journal of Radiological Medicine and Protection,2007,27(2):138-139 |
| Quantitative analysis of the effect of basic fibroblast growth factor on radiation induced blood brain barrier disruption |
| Received:August 14, 2006 |
| DOI： |
| KeyWords:Radiation induced brain injury Blood brain barrier Basic fibroblast growth factor |
| FundProject:广东省医学科学技术研究基金资助项目(NB2004048 ,96-06) |
| Author Name | Affiliation | E-mail | | LIU Yun-lin | Department of Neurology, The Second Affiliated Hospital of SUN Yat-sen University, Guangzhou 510120, China | | | ZHOU Hai-hong | Department of Neurology, The Second Affiliated Hospital of SUN Yat-sen University, Guangzhou 510120, China | | | LI Xi-ming | 天津市胸科医院 | | | 贺峰 | Department of Neurology, The Second Affiliated Hospital of SUN Yat-sen University, Guangzhou 510120, China | | | 黄仕雄 | Department of Neurology, The Second Affiliated Hospital of SUN Yat-sen University, Guangzhou 510120, China | | | 邢诒刚 | Department of Neurology, The Second Affiliated Hospital of SUN Yat-sen University, Guangzhou 510120, China | yigangxing@126.com |
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| Abstract:: |
| Objective To evaluate the different detection methods of blood brain barrier(BBB) disruption, and to explore the protection effect of basic fibroblast growth factor(bFGF) on the BBB disruption. Methods 60 rats were classified into radiation group, bFGF intravenous injection group and contol group. The water content of brain was measured by wet-dry weight formula and Evans blue(EB) concentration was detected after intravenous injection(3 mg/kg) after 2,7 and 30 days post irradiation in each group. The data were collected and analysed to evaluate the degree of BBB disruption. Results Both of EB concentration and water content in brain increased after irradiation, which were lower in bFGF injection group than those in radiation group (P<0.05). Statistic difference (P<0.05) was found at different days following exposure for EB concentration but not for water content in brain. Conclusions It's more effective of EB concentration to represent the BBB disruption than of water content. Intravenous injection of bFGF may have some protective effects on BBB disruption induced by radiation. |
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