| FANG Tong,REN Jian,CHEN Li.Study on the clinical effect of fractionated total body irradiation before hematopoietic stem cell transplantation[J].Chinese Journal of Radiological Medicine and Protection,2007,27(1):70-72 |
| Study on the clinical effect of fractionated total body irradiation before hematopoietic stem cell transplantation |
| Received:March 28, 2006 |
| DOI： |
| KeyWords:Hematopoietic stem cell Transplantation Pretreatment Total body irradiation Absorbed dose rate |
| FundProject: |
| Author Name | Affiliation | | FANG Tong | Department of Radiation Oncology, Beijing Shijitan Hospital, Beijing 100038, China | | REN Jian | Department of Radiation Oncology, Beijing Shijitan Hospital, Beijing 100038, China | | CHEN Li | Department of Radiation Oncology, Beijing Shijitan Hospital, Beijing 100038, China | | 孙保锦 | Department of Radiation Oncology, Beijing Shijitan Hospital, Beijing 100038, China |
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| Abstract:: |
| Objective To observe the dose level and complications of total body irradiation (TBI) before hematopoietic stem cell transplantation. Methods 312 patients with TBI before heamatopoietic stem cell transplantation were enrolled into the study from May 1999 to October 2005. All patients were irradiated with 60Co γ-rays in 2 days at the dose rate of (5.2±1.13) cGy/min, once per day. The total dose of TBI was 7-12 Gy.The high dose group (≥10 Gy)had 139 cases, and the low dose group (<10 Gy)had 173 cases. The toxic reactions, hematopoietic reconstitution and graft survival rate were compared. Results The rate of acute gastrointestinal reactions and oral inflammation in the high dose group was significantly higher than that in the low dose group (P<0.05). The other reactions, hematopoietic reconstitution and graft survival rate was insignificantly different. Conclusions Fractional total body irradiation in 2 days with dose rate of 5 cGy/min, once per day, total dose of 7-12 Gy, the median lung absorbed dose under 7.5 Gy is a safe and effective pretreatment for hematopoietic stem cell transplantation. |
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