| GUO Mei,AI Hui-sheng,YU Chang-lin.Management of two patients with intestinal form of acute radiation sickness and extremely severe bone marrow form of acute radiation sickness complicated with disseminated fungous infection[J].Chinese Journal of Radiological Medicine and Protection,2007,27(1):17-18 |
| Management of two patients with intestinal form of acute radiation sickness and extremely severe bone marrow form of acute radiation sickness complicated with disseminated fungous infection |
| Received:September 18, 2006 |
| DOI： |
| KeyWords:Acute radiation sickness Fungous infection Ampghotec (amphotericin B) Caspofungin(concidas) Itraconazole |
| FundProject: |
| Author Name | Affiliation | E-mail | | GUO Mei | Department of Radiaton Medicine Hematology, Affiliated Hospitol, Academy of Military Medical Sciences, Beijing 100071, China | | | AI Hui-sheng | Department of Radiaton Medicine Hematology, Affiliated Hospitol, Academy of Military Medical Sciences, Beijing 100071, China | huishengai@163.com | | YU Chang-lin | Department of Radiaton Medicine Hematology, Affiliated Hospitol, Academy of Military Medical Sciences, Beijing 100071, China | | | 乔建辉 | Department of Radiaton Medicine Hematology, Affiliated Hospitol, Academy of Military Medical Sciences, Beijing 100071, China | | | 王丹红 | Department of Radiaton Medicine Hematology, Affiliated Hospitol, Academy of Military Medical Sciences, Beijing 100071, China | | | 孙琪云 | Department of Radiaton Medicine Hematology, Affiliated Hospitol, Academy of Military Medical Sciences, Beijing 100071, China | | | 张石 | Department of Radiaton Medicine Hematology, Affiliated Hospitol, Academy of Military Medical Sciences, Beijing 100071, China | | | 葛飞娇 | Department of Radiaton Medicine Hematology, Affiliated Hospitol, Academy of Military Medical Sciences, Beijing 100071, China | | | 张锡刚 | Department of Radiaton Medicine Hematology, Affiliated Hospitol, Academy of Military Medical Sciences, Beijing 100071, China | | | 李光 | Department of Radiaton Medicine Hematology, Affiliated Hospitol, Academy of Military Medical Sciences, Beijing 100071, China | | | 牛文凯 | Department of Radiaton Medicine Hematology, Affiliated Hospitol, Academy of Military Medical Sciences, Beijing 100071, China | |
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| Abstract:: |
| Objective To present two patients diagnosed as intestinal form of acute radiation sickness (patient A) and extremely severe bone marrow form of acute radiation sickness(patient B) complicated with disseminated fungous infection in China. Methods On October 21st, 2004, a nuclear accident occurred in Jining, Shandong Province, China. Two individuals were accidentally irradiated by a 60Co source. They were transferred to our hospital, and performed allogeneic stem cell transplantation and soon acquired hematopoisis recovery; however, refractory disseminated fungous infection occurred in two patients. Results High dosage of amphotericin B combined with itraconazole and concidas were used to kill fungi. The infection was once controlled, but the radiation injury and infection were still becoming worse even after many kinds of treatment. The patients finally died of multiple organ failure on day 33 and day 75, respectively after the accident. Conclusions The combination of Ampghotec (amphotericin B) with Caspofungin(concidas) and Itraconazole in the treatment of disseminated fungous infection was effective and with no related toxicity. But during the continuous injury of radiation, we couldn't eradicate the fungous infection. The patients were finally died of multiple organs failure related with radiation and infection. |
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