| PAN Min-hong,PENG Rui-yun,WANG Shui-ming.Effect of S-band high power microwave radiation on primary cultured neonatal cardiomyocytes[J].Chinese Journal of Radiological Medicine and Protection,2006,26(6):625-627 |
| Effect of S-band high power microwave radiation on primary cultured neonatal cardiomyocytes |
| Received:March 06, 2006 |
| DOI： |
| KeyWords:High power microwave Cardiomyocyte Apoptosis [Ca2+]i Membrane electroporation |
| FundProject:国家“863”课题资助项目 |
| Author Name | Affiliation | E-mail | | PAN Min-hong | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | pengry@nic.bmi.ac.cn | | PENG Rui-yun | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | WANG Shui-ming | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | 高亚兵 | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | 马俊杰 | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | 徐新萍 | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | 王德文 | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | 徐天昊 | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | 董波 | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | 周红梅 | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | |
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| Abstract:: |
| Objective To investigate the effect of S-band high power microwave(HPM) radiation on primary cultured neonatal cardiomyocytes and explore its possible mechanism. Methods Primary cultured neonatal cardiomyocytes were radiated with S-band HPM radiation with mean power density of 5-30 mW/cm2.Flow cytometry and atom force microscopy were used to determine the rates of apoptosis and necrosis,calcium ion concentration,and the structure of cell membrane. Results HPM radiation of 10-30 mW/cm2 increased the rates of apoptosis and necrosis(P<0.05 or P<0.01)and calcium ion concentration(P<0.01),and caused membrane electroporation in cardiomyocytes. Conclusions HPM may increase the rates of apoptosis and necrosis,cause calcium overload and membrane electroporation.Such changes play an important role in heart injury induced by HPM radiation. |
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