| GU Ke,ZHANG Jun-ning.Clinical assessment of radiotherapy for cancers with bone metastases[J].Chinese Journal of Radiological Medicine and Protection,2006,26(6):595-597 |
| Clinical assessment of radiotherapy for cancers with bone metastases |
| Received:January 10, 2006 |
| DOI： |
| KeyWords:Carcinoma Bone metastases Radiotherapy |
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| Abstract:: |
| Objective To estimate median survival time (MST) and assess pain-relief effect of radiotherapy for bone metastatic cancers. Methods During the period from July 1999 to June 2003, 79 cases of malignant tumors with 141 bone metastases were treated by 6 or 15 MV X-rays. Of the all cases, 18 cases were irradiated with conventional fraction: 20-25 times of irradiation during 4-5 weeks, 40-50 Gy in total; 61 cases were treated with lower fraction: 10-12 fractions during 2-2.5 weeks, 30-36 Gy in total. Results (1) Overall MST was estimated to be 3.81 months. MSTs of patients with bone metastases only and patients with both internal organ and bone matastases were 8.05 months and 3.10 months, respectively; the difference between the two kinds of patients was statistically significant (P<0.05). MSTs of those cases with primary lesion controlled and those cases with primary lesion uncontrolled or unspecified were 4.29 months and 3.31 months, respectively; the differences between them was statistically significant (P<0.05). However, the difference of MST between cases with single bone metastatic site and multiple bone metastatic sites was not significant (P>0.05). (2) The overall rate of pain-relief with radiotherapy was 92.90%, and not influenced by control of primary lesion, the number of bone metastatic sites, internal organ metastases, and dose fraction. (3) The relief of ostealgia occurred more promptly after irradiation with higher dose per fraction. Conclusions Radiotherapy could not only help to improve survival of bone metastatic carcinomas, but also be used as an effective and efficient treatment of ostealgia. |
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