| WANG Zhi-cheng,ZHAO Hong-guang,DU Xiang,et al.Protective effects of oleum curcumae wenchowensis on skin damage due to UVB[J].Chinese Journal of Radiological Medicine and Protection,2006,26(5):533-535 |
| Protective effects of oleum curcumae wenchowensis on skin damage due to UVB |
| Received:January 18, 2006 |
| DOI： |
| KeyWords:Oleum curcumae wenchowensis Ultraviolet B Antioxidant Protection |
| FundProject:浙江省科技计划重大项目基金资助(2006-2008) |
| Author Name | Affiliation | E-mail | | WANG Zhi-cheng | MH Radiobiology Research Unit, School of Public Health, Jilin University, Changchun 130021, China | gongsl@163.com | | ZHAO Hong-guang | MH Radiobiology Research Unit, School of Public Health, Jilin University, Changchun 130021, China | | | DU Xiang | MH Radiobiology Research Unit, School of Public Health, Jilin University, Changchun 130021, China | | | 李艳博 | MH Radiobiology Research Unit, School of Public Health, Jilin University, Changchun 130021, China | | | 郭伟 | MH Radiobiology Research Unit, School of Public Health, Jilin University, Changchun 130021, China | | | 肖健 | 温州医学院生物与天然药物研究院 | | | 姚崇舜 | 温州医学院生物与天然药物研究院 | | | 李校堃 | 温州医学院生物与天然药物研究院 | | | 龚守良 | MH Radiobiology Research Unit, School of Public Health, Jilin University, Changchun 130021, China | |
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| Abstract:: |
| Objective To study the protective effects of oleum curcumae wenchowensis on skin damage exposed to UVB and its mechanism,and to provide the experimental basis for the protection of skin damage exposed to UVB. Methods The skin of guinea pigs was exposed to UVB (28.38 J/cm2·30 d) to establish the oxidative damage model.The skin erythema and the rough were observed during the experiment; the thickness of epiderm and the number of fibroblast were observed under light microscope after the experiment.The activities of GSH-Px,SOD,CAT and T-AOC and the contain of MDA in the supernate of skin homogenate were detected with biochemical methods. Results The epiderm in UVB exposure group and blank group thickened,but that in protective group weren't observed; the number of fibroblast in UVB exposure group and blank group decreased,while that in protective group increased,but that in control group didn't.The content of MDA in the supernate of skin homogenate in UVB exposure group and blank group increased,but that in proctective group deceased,and the activities of GSH-Px,SOD,CAT and T-AOC in UVB exposure group and blank group decreased,but those in proctective group increased,and control group had no change. Conclusions Oleum curcumae wenchowensis has the proctective effects on skin damage exposed to UVB,which may be mediated by increasing the contain of antioxidases and eliminating the free radical. |
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