| Chen Wei-min,Lin Tian-sheng,Wang Shen.Clinical observation on strontium-89-chloride therapy in elder patients with prostate cancer for palliation of pain from bone metastases[J].Chinese Journal of Radiological Medicine and Protection,2006,26(5):501-502 |
| Clinical observation on strontium-89-chloride therapy in elder patients with prostate cancer for palliation of pain from bone metastases |
| Received:March 01, 2006 |
| DOI： |
| KeyWords:Strontium Radionuclide therapy Prostate cancer Bone metastatics Bone pain |
| FundProject: |
| Author Name | Affiliation | | Chen Wei-min | Department of Nuclear medicine, Union Hospital Affiliated to Fujian Medical University, Fuzhou, 350001, China. | | Lin Tian-sheng | Department of Nuclear medicine, Union Hospital Affiliated to Fujian Medical University, Fuzhou, 350001, China. | | Wang Shen | Department of Nuclear medicine, Union Hospital Affiliated to Fujian Medical University, Fuzhou, 350001, China. | | 陈谭英 | Department of Nuclear medicine, Union Hospital Affiliated to Fujian Medical University, Fuzhou, 350001, China. |
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| Abstract:: |
| Objective To estimate clinical curative efficacy and adverse reaction of 89Sr-chloride therapy for palliation of pain from bone metastases in the older patients with prostate cancer. Methods 48 cases of older patients with metastatic prostate cancer with bone pain were studied after androgen deprivation therapy. 89Sr-chloride were administrated iv for the palliative treatment of metastatic bone pain. The curative effects in patients were investigated, including palliation of pain, change of metastatic focus,the tumor sign of PSA, and the adverse reaction. Results After 89Sr-chloride therapy, the total palliation rate was 89.6%, inefficiency rate was 10.4%, while metastatic focus and PSA decreased to some extent. No severe adverse reaction occurred. Conclusions It is shown that the curative efficacy of acesodyne is evident after 89Sr-chloride therapy in older patients suffering from bone metastase with prostate cancer. It is an effective therapeutic method for the palliation of pain from bone metastases especiallly to the older patients with multiple metastatases. |
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