| PAN Jian-ji,HONG Jin-sheng,ZHANG Yu.Risk factors of conventional irradiation-induced lower cranial neuropathy in patients with nasopharyngeal carcinoma[J].Chinese Journal of Radiological Medicine and Protection,2006,26(5):490-493 |
| Risk factors of conventional irradiation-induced lower cranial neuropathy in patients with nasopharyngeal carcinoma |
| Received:November 23, 2005 |
| DOI： |
| KeyWords:Nasopharyngeal neoplasm Radiotherapy Irradiation injury Cranial nerve disease |
| FundProject:福建省科技计划资助项目(2000Z040) |
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| Abstract:: |
| Objective To study the risk factors of radiation-induced lower cranial neuropathy (RILCN) after conventional radiotherapy in patients with nasopharyngeal carcinoma, and to improve the radiotherapeutic planning. Methods A hundred cases received radical radiotherapy of nasopharyngeal carcinoma and 200 individual matched controls on sex, age and time to start the radiotherapy were studied. Conditional logistic regression model was used to analyze 13 risk factors related to development of RILCN. Results Conditional logistic regression analysis revealed that cigarette smoking, irradiation scheme, radiation dose to the superior neck, neck fibrosis and acute radiation-related dermatitis of neck were risk factors of RILCN, their relative risks were 4.594, 2.629, 1.072, 4.141 and 2.531, respectively. Among three external irradiation schemes, it is found that pre-auricular portal plus whole neck tangential portal irradiation had the highest risk of RILCN. Conclusions The study suggested that the irradiation scheme of pre-auricular portal plus whole neck tangential portal should be no longer used. |
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