| XIA Guang-rong,LIU Gui-mei,JIN Guo-hua.Clinical study on tumor radiosensitizer CMNa[J].Chinese Journal of Radiological Medicine and Protection,2006,26(5):470-472 |
| Clinical study on tumor radiosensitizer CMNa |
| Received:January 17, 2006 |
| DOI： |
| KeyWords:Radiotherapy CMNa Radiosensitizer |
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| Abstract:: |
| Objective To verify the role of glycodidazolum natrium (CMNa) in enhancing radiosensitivity of tumors. Methods A double-blind randomized clinical trial was performed. Fifty-five cancer cases of the lungs or esophagus were randomly classified into two groups, one group (Group A) was treated with radiotherapy plus CMNa, and the control group (Group B) with radiotherapy plus placebo. Radiotherapy was administered by conventional schedule: 2 Gy per fraction, 5 fractions per week, 60～70 Gy in total during 6～7 weeks. CMNa was given by intravenous drip at a dose of 800 mg/m2 on day 1,3,and 5 per week throughout the course of treatment. Radiotherapy was started 30-60 minutes after completion of CMNa infusion. Results Among the patients of lung cancer, the CR+PR rate was 42% in Group A and 53% in Group B, respectively (P=0.516). Among the patients of esophageal carcinoma, the CR+PR rate was 100% in Group A and 43% in Group B, respectively (P=0.015). The mean survival time in Group A was 11 months, and 10 months in Group B. The 1-, 3-, and 5-year local control rates were 32%, 18%, 16% in Group A, and 28%, 19%, 13% in Group B, respectively; and the difference of local control rates between the two groups were not statistically significant (P=0.518). The 1-, 3-, and 5-year survival rates were 31%, 13% and 10% in Group A and 25%, 15% and 6% in Group B (P=0.475). There was no serious side-effect. Conclusions CMNa increased the radiotherapeutic effect in the treatment of esophageal carcinoma, but almost no effect for lung cancer. CMNa administered with radiotherapy was also well-tolerated. Long-term effect was not satisfactory. Further study with large sample-size is needed. |
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