| YIN Li-jie,ZHANG Li,DING Tian-gui.Radiosensitization effect of CMNa on hypoxic pancreatic cancer cell in vitro[J].Chinese Journal of Radiological Medicine and Protection,2006,26(5):467-470 |
| Radiosensitization effect of CMNa on hypoxic pancreatic cancer cell in vitro |
| Received:November 23, 2005 |
| DOI： |
| KeyWords:Pancreatic cancer cell Radiosensitivity Cell hypoxia CMNa |
| FundProject: |
| Author Name | Affiliation | | YIN Li-jie | Department of Radiotherapy, Dalian Central Hospital, Dalian 116033, China | | ZHANG Li | 116033, 大连大学医学院附属大连中心医院实验室 | | DING Tian-gui | Department of Radiotherapy, Dalian Central Hospital, Dalian 116033, China | | 彭兆祥 | Department of Radiotherapy, Dalian Central Hospital, Dalian 116033, China | | 于环 | 116033, 大连大学医学院附属大连中心医院实验室 | | 高玉伟 | Department of Radiotherapy, Dalian Central Hospital, Dalian 116033, China |
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| Abstract:: |
| Objective To investigate the effects of glycodidazolum natrium(CMNa) on pancreatic cancer cells under hypoxic condition. Methods The human pancreatic cancer Panc-1 cells were exposed to a single fraction of high-dose γ-ray radiation either with CMNa or under hypoxic condition. The percentage of dead cells was detected with a multiwell plated reader, and fluorescence intensities of propidium iodide were measured before and after digitonin treatment. The sensitizing effect of CMNa on cell killing induced by high-dose irradiation was evaluated by time and concentration dependence. The selective radiosensitive effect of CMNa on hypoxia was evaluated by flow cytometry. Results The death rate of pancreatic cancer Panc-1 cells paralleled with the increasing concentration of CMNa under hypoxic condition after 30 gray irradiation. The selective radiosensitive effect of CMNa on hypoxia was time-dependent. Conclusions CMNa can enhance the radiosensitivity of pancreatic cancer Panc-1 cells under hypoxic condition with high-dose irradiation. |
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