| GAO Hong,LI li-jun,FENG Guo-sheng.Radiochemotherapy with interstitial implantation of 125I seeds and 5-FU slow-released seeds for recurrent colorectal adenocarcinoma[J].Chinese Journal of Radiological Medicine and Protection,2006,26(4):381-382 |
| Radiochemotherapy with interstitial implantation of 125I seeds and 5-FU slow-released seeds for recurrent colorectal adenocarcinoma |
| Received:January 08, 2006 |
| DOI： |
| KeyWords:Colorectal carcinoma 125I seeds 5-FU slow-release seeds Brachytherapy |
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| Abstract:: |
| Objective To investigate the feasibility, security, and short-term efficacy of combined treatment of interstitial implantation of 125I seeds and 5-FU slow-released seeds for recurrent colorectal adenocarcinoma. Methods From December 2001 to December 2005, 26 cases of recurrent colorectal adenocarcinoma underwent Mile's procedure were treated with the radiochemotherapy.We implanted alternately 125I seeds and 5-FU slow-released seeds following the treatment planning system.The matched peripheral dose (MPD) of 125I seed implantation was 90-130 Gy. Twelve granules of 125I seeds and 600 mg of 5-FU were administered in every patient on average. Results No operation-related complication was occurred during the implantations for all the cases. No displacement of 125I seed was found by pelvic X-ray examination.Lenitive rate of the pain was 88.9% (16/18).The relief has lasted for 5-10 days on average. CT scanning showed that the size of tumor reduced in various degree at 3-6 months after the implantation.The complete recovery rate was 7.7% (2/26), the partial recovery rate was 73.1% (19/26).The PD was 15.4% (4/26).The median survival time was 29 months estimated by following these cases for 6-42 months. One case died of bone and lung metastases at 6 months after the implantation. Conclusion Combined radiochemotherapy with interstitial implantation of 125I seeds and 5-FU slow-released seeds was a safe and effective microinvasive treatment for recurrent colorectal carcinoma. |
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