| DONG Ming-xin,ZHAO Tong,HUANG Jing-zi.Selection of optimal treatment scheme for brain metastases of non-small cell lung cancer[J].Chinese Journal of Radiological Medicine and Protection,2006,26(4):371-373 |
| Selection of optimal treatment scheme for brain metastases of non-small cell lung cancer |
| Received:January 08, 2006 |
| DOI： |
| KeyWords:Brain metastases Chemotherapy of Vm-26 Gamma knife |
| FundProject: |
| Author Name | Affiliation | | DONG Ming-xin | Second Hospital of Northern China College, Jinlin 132022, China | | ZHAO Tong | Second Hospital of Northern China College, Jinlin 132022, China | | HUANG Jing-zi | Second Hospital of Northern China College, Jinlin 132022, China | | 余淑坤 | Second Hospital of Northern China College, Jinlin 132022, China | | 冯燕 | Second Hospital of Northern China College, Jinlin 132022, China | | 田中成 | Second Hospital of Northern China College, Jinlin 132022, China | | 金香顺 | Second Hospital of Northern China College, Jinlin 132022, China | | 全吉钟 | Second Hospital of Northern China College, Jinlin 132022, China | | 刘金 | Second Hospital of Northern China College, Jinlin 132022, China | | 王冬旭 | Second Hospital of Northern China College, Jinlin 132022, China |
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| Abstract:: |
| Objective To select the optimal treatment scheme for brain metastases of non-small cell lung cancers (NSCLCs). Methods Seventy-two NSCLC cases diagnosesd by pathology with brain metastases were randomly classified into three groups, Group Ⅰ, 24 cases with whole brain conventional external fractioned irradiation of DT 36-41 Gy/4-5 w, Group Ⅱ, 22 cases with γ-knife treatment plus whole brain conventional external fractioned irradiation, and Group Ⅲ, 26 cases with γ-knife plus whole brain conventional external fractioned irradiation in combination with chemotherapy of Vm-26. The surrounding area of tumor was strictly covered with 50% para-central-dosal curve in γ-knife treatment (DT 16-25 Gy with a mean of 16 Gy). The mult-leaf collimator was selected according to the volume of tumors. Chemotherapy of Vm-26 (60 mg/m2 d1-3) was applied during the treatment with whole brain conventional external fractioned irradiation (DT 19-29 Gy/2-3 w), 21 days in a period, 2 periods in total. Results The median survival time was estimated to be 6.0 months (ranged from 1.2 to 19.0 months) in the Group Ⅰ, 9.2 months (4.4-30 months) in the Group Ⅱ, and 10.8 months (5.2-42.2 months) in the Group Ⅲ. The 1-year and 2-year survival rates were 34.6% and 12.6%, 62.2% and 30.2%, and 70.8% and 35.6% respectively in Group Ⅰ, Group Ⅱ, and Group Ⅲ, respectively. Conclusion For brain metastases of NSCLC, γ-knife plus whole brain conventional external fractioned irradiation combined with treatment of Vm-26 had a significantly beneficial influence on improvement of the local control and 1-year and 2-year survival. There was no complaint about the side-effects of the treatment. |
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