| YANG Kun-yu,LIU Li,ZHANG Tao,et al.Increased expressions of MMP-2 and MMP-9 in lung following 12 Gy local irradiation[J].Chinese Journal of Radiological Medicine and Protection,2006,26(4):360-363 |
| Increased expressions of MMP-2 and MMP-9 in lung following 12 Gy local irradiation |
| Received:January 18, 2006 |
| DOI： |
| KeyWords:Metalloproteinases (MMPs) Tissue inhibitors of metalloproteinases (TIMPs) Radiation-induced lung damage |
| FundProject: |
| Author Name | Affiliation | E-mail | | YANG Kun-yu | Wuhan Union Hospital Cancer Center, Tongji Medical College, Huazhong Science and Technology University, Wuhan 430023, China | wanggangzr@yahoo.com.cn | | LIU Li | Wuhan Union Hospital Cancer Center, Tongji Medical College, Huazhong Science and Technology University, Wuhan 430023, China | | | ZHANG Tao | Wuhan Union Hospital Cancer Center, Tongji Medical College, Huazhong Science and Technology University, Wuhan 430023, China | | | 胡豫 | 430023 武汉, 华中科技大学同济医学院附属协和医院血液学研究所 | | | Claudia Ruebe | Department of Radiation Oncology Saarland University Hospital, Germary, Department of Radiation Oncology, Saarland University Hospital | | | Christian Ruebe | Department of Radiation Oncology Saarland University Hospital, Germary, Department of Radiation Oncology, Saarland University Hospital | | | 伍钢 | Wuhan Union Hospital Cancer Center, Tongji Medical College, Huazhong Science and Technology University, Wuhan 430023, China | |
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| Abstract:: |
| Objective To measure expressions of metalloproteinases and tissue inhibitors of metalloproteinases in the lung following thoracic irradiation of 12 Gy, and explore its possible role in the development of radiation-induced lung damage. Methods C57BL/6J mice at age of 8 weeks were thoracically irradiated with 12 Gy X-rays (10 MV, 2.4 Gy/min, single exposure), and the control mice were sham-irradiated. The mice were sacrificed at 4 or 8 weeks after thoracic iradiation by decapitation. Lung tissues samples were collected. Expressions of MMP-2, MMP-9, MMP-3, MMP-13, TIMP-1, TIMP-2, and TIMP-3 in lung samples were measured. Results There was no significant difference in expressions of MMP-3, MMP-13, TIMP-1 TIMP-2, and TIMP-3 in the lung between the two groups at 4 and 8 weeks after thoracic irradiation (or sham-irradiation). However, the expressions of MMP-2 were enhanced by 1.7 and 1.9 folds, and MMP-9 by 2.7 and 2.6 folds at 4 and 8 weeks after thoracic irradiation,respectively. Conclusion Enhanced expressions of MMP-2 and MMP-9 in the lung were involved in the development of acute lung injury after thoracic irradiation, leading to a disruption of the structure and fibrosis. |
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