| GAO Yong,HAO En-zhu,NI Yan-bo.Influence of cigarette smoke and green tea on radiation-induced micronucleated polychromatic erythrocytes[J].Chinese Journal of Radiological Medicine and Protection,2006,26(4):355-357 |
| Influence of cigarette smoke and green tea on radiation-induced micronucleated polychromatic erythrocytes |
| Received:October 20, 2005 |
| DOI： |
| KeyWords:Radiation Cigarette Green tea Mutation |
| FundProject:滨州医学院科技计划基金资助项目(03K08) |
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| Abstract:: |
| Objective To observe the effects of cigarette smoke and green tea on radiation-induced bone marrow cell mutation, and to provide scientific information for prevention and treatment of radiation damage. Methods There were 8 groups in the factorial experiment design with 3 factors at 2 levels. Mice were randomly divided into each group. There were 8 mice in each group. Mice in seven experimental groups were exposed to cigarette smoke, green tea, radiation or their mixtures respectively. One group was treated as the blank control group. The frequencies of micrnucleated polychromatic erythrocytes (MPCE) were scored by single blinded method. The data were analyzed with factorial experiment's analysis of variance using SAS 8.0. Results Analysis of variance showed that radiaton, cigarette smoke and green tea were independently significant factors (P<0.01). Interactions between cigarette smoke and radiation or between green tea and radiation were statistically significant (P<0.01). Conclusion Radiaton and cigarette smoke can cause bone marrow cell mutations independently. There is synergistic effect between cigarette smoke and radiation. Green tea can inhibit radiation-induced cell mutation. |
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