| LI Zhi-qiang,YUE Jia-yi,QU Yi-hua.Study on changes of the plasma cytokines in 60Co γ-ray irradiated blood and leukocyte reduction of whole blood[J].Chinese Journal of Radiological Medicine and Protection,2006,26(4):349-351 |
| Study on changes of the plasma cytokines in 60Co γ-ray irradiated blood and leukocyte reduction of whole blood |
| Received:October 18, 2005 |
| DOI： |
| KeyWords:60Co γ-ray Irradiation Leukocyte reduction sets Blood Cytokine |
| FundProject:上海市卫生局科技发展基金资助项目(034054) |
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| Abstract:: |
| Objective To study the changes of IL-2,IL-6,IFN-γ and TNF-α in 60Coγ -ray irradiated and leukocyte reduction of whole blood, and to understand the fever phenomenon in patients received blood transfusion. Methods ELISA method was used to measure changes of the cytokines. Results The plasma levels of IL-2,IL-6,IFN-γ and TNF-α did not change significantly with extending the conservation period both in 60Coγ -irradiated and leukocyte reduction of whole blood. The frequency of fever decreaed obviously with transfusion of 60Coγ -irradiated and leukocyte reduction of whole blood. Conclusion 60Coγ -irradiated blood can not only prevent transfusion associated graft-versus-host disease(TA-GVHD), but also decrease non-hemolytic febrile transfusion reactions (NHFTR) effectively. |
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