| FENG Chong-jin,GUO Jun-bing,LI Chu-yu.Establishment of murine model of radiation-induced oral mucositis[J].Chinese Journal of Radiological Medicine and Protection,2006,26(4):346-348 |
| Establishment of murine model of radiation-induced oral mucositis |
| Received:January 08, 2006 |
| DOI： |
| KeyWords:Oral mucositis Radioactivity Animal model Rat |
| FundProject:广东省科技计划基金资助项目(2004B34001003) |
| Author Name | Affiliation | | FENG Chong-jin | Department of Stomatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China | | GUO Jun-bing | Department of Stomatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China | | LI Chu-yu | 510080 广州, 中山大学附属肿瘤医院放疗科 | | 王汉渝 | 510080 广州, 中山大学附属肿瘤医院放疗科 | | 李春阳 | 510080 广州, 中山大学附属口腔医院 | | 曹新平 | 510080 广州, 中山大学附属肿瘤医院放疗科 | | 程斌 | 510080 广州, 中山大学附属口腔医院 |
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| Abstract:: |
| Objective To establish a murine model of radiation-induced oral mucositis. Methods Left-sided buccal mucosa of 70 Sprague-Dawley rats were irradiated with X-rays (10 Gy/d), then six rats, selected randomly, were sacrificed at the 2nd, 4th, 6th, 8th, 14th, and 21st day after the irradiation, left-sided buccal mucosa were excised, corresponding irradiation dose for the selected rats were 20, 40, 60 and 80 Gy following radiation. The right buccal mucosa was excised and treated as its auto-controls tissue. Results Erythema was observed in the left-sided buccal mucosa in rates irradiated with X-rays of 60 Gy; a single or more ulcers observed in rates irradiated with 80 Gy X-rays; a large area of ulcer was observed at 4th day after 80 Gy irradiation. The radiation-induced ulcer in buccal mucosa was essentially recovered after about 2 weeks following 80 Gy irradiation. Conclusion This murine model of radiation-induced oral mucositis was useful and practical in experimental studies. |
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