| DAI Guang-fu,JIN Yue-ying,TIAN Yuan.An experimental study of 131I microdistribution at cellular level[J].Chinese Journal of Radiological Medicine and Protection,2006,26(4):332-334 |
| An experimental study of 131I microdistribution at cellular level |
| Received:December 26, 2005 |
| DOI： |
| KeyWords:Cell level Microautoradiography Argent grain 131I |
| FundProject:国家自然科学基金资助项目(10375091) |
| Author Name | Affiliation | | DAI Guang-fu | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin 300192, China | | JIN Yue-ying | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin 300192, China | | TIAN Yuan | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin 300192, China | | 苑淑渝 | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin 300192, China | | 张良安 | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin 300192, China |
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| Abstract:: |
| Objective Traditional MIRD method for dose assessment in nuclear medicine assumes that radionuclide is homogeneously distributed in organs, the dose to cell and cell nucleus is presented by the mean dose to the organ. However, this assumption is hardly satisfication because of various factors, such as nuclide and its carrier, organ/cell and so on. Understanding micro-dose (i.e., doses at cell, meta-cell and molecule levels) distribution of radionuclide is an essential element for stipulating detailed plan for diagnosis and treatment in clinical nuclear medicine, as well as an important factor for predicting and assessing radio-pharmaceuticals effect. Methods In this work, the micro distribution of 131I is described using microautoradiogtraphy and frozen sectioning technique. Results To describe the relationship between argent grain density and nuclide radioactivity a regression curve was depicted, and the R value calculated was 0.9963. The scale coefficient of argent grain was 1.59×10-4 Bq. Conclusion The distribution of radiomedicament 131I at cellular level is nonuniform. |
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