| FAN Wei,CHEN Li-xin,LIU Xiao-wei,et al.Comparison of Monte Carlo simulation and MIRD methods for absorption dose calculation of 153Sm_EDTMP[J].Chinese Journal of Radiological Medicine and Protection,2006,26(3):280-282 |
| Comparison of Monte Carlo simulation and MIRD methods for absorption dose calculation of 153Sm_EDTMP |
| Received:June 29, 2005 |
| DOI： |
| KeyWords:Monte Carlo method MIRD method ~ 153 Sm-EDTMP Absorption dose |
| FundProject:广东省自然科学基金资助项目(031563);广州市科技攻关重点项目(2002Z2-E0131) |
| Author Name | Affiliation | | FAN Wei | Department of Nuclear Medicine, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China | | CHEN Li-xin | Department of Nuclear Medicine, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China | | LIU Xiao-wei | 510060 广州, 中山大学理工学院 | | 游日安 | Department of Nuclear Medicine, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China | | 唐强 | 510060 广州, 中山大学理工学院 | | 王国慧 | Department of Nuclear Medicine, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China | | 张伟光 | Department of Nuclear Medicine, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China | | 干峰 | Department of Nuclear Medicine, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China |
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| Abstract:: |
| Objective With Monte Carlo and MIRD methods respectively, the absorption dose of 153Sm-EDTMP was calculated in different target organs of nasopharygeal carcinoma (NPC) patient so as to explore their clinical value. Methods Based on time-order SPECT/CT infusion imaging and 153Sm-EDTMP assay of patient urine, the absorption dose of bone lesion and the different organs were calculated with Monte Carlo EGS4 and MIRD methods. Results The internal nuclide dose results showed that the maximum absorption dose of left hipbone metastatic focus was 5.6 Gy after 33.6×37 MBq of 153Sm-EDTMP injection. The dose of focus margin was 2.0 Gy, and the relative absorption dose value of vertebral body, bone cortex, bone marrow,cone body, soft tissue in pelvic cavity were 12%, 13%、21% and 2% respectively. Conclusion The accurate nuclide absorption dose with Monte Carlo method based on SPECT/CT image can guide nuclide-targeted radiotherapy, but MIRD method maybe used to evaluate to the bone morrow toxicity. |
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