| GUAN Li_ming,XIA Bing,GUO Min,et al.Treatment of rat C6 gliomas with X-knife and its acute therapeutic effects[J].Chinese Journal of Radiological Medicine and Protection,2006,26(3):261-263 |
| Treatment of rat C6 gliomas with X-knife and its acute therapeutic effects |
| Received:September 06, 2005 |
| DOI： |
| KeyWords:Glioma Radiosurgery Tomography X_ray computed Rat |
| FundProject: |
| Author Name | Affiliation | E-mail | | GUAN Li_ming | Department of Radiology, First Hospital of China Medical University, Shenyang 110001, China | xuke@cmuimaging.com | | XIA Bing | 110001 沈阳, 中国医科大学附属第一医院放射肿瘤科 | | | GUO Min | Department of Radiology, First Hospital of China Medical University, Shenyang 110001, China | | | 徐克 | Department of Radiology, First Hospital of China Medical University, Shenyang 110001, China | | | 赵宇 | Department of Radiology, First Hospital of China Medical University, Shenyang 110001, China | | | 徐炳学 | 110001 沈阳, 中国医科大学附属第一医院放射肿瘤科 | | | 张朔 | 110001 沈阳, 中国医科大学附属第一医院放射肿瘤科 | | | 姚雷 | 110001 沈阳, 中国医科大学附属第一医院放射肿瘤科 | | | 段红杨 | 中国航空部中心医院放射科 | |
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| Abstract:: |
| Objective To study the feasibility of target positioning in X_knife treatment on rat C6 gliomas and its acute therapeutic effects on the tumor. Methods To established animal model C6 cells were inoculated into the right caudate nucleus for 20 Wistar rats by stereotactic procedure.On the 16th day after inoculation of C6 cells,tumor_bearing rats were treated with X_knife,5 mm collimator and combination CT plain images with large field to the enhancement images of small field based on the latter was used to sketch the target position through the 3D workstation,20 Gy in total.The acute therapeutic effect of X_knife treatment was evaluated with comparison to conditions of the rats in the tumor group. Results There were 7 tumor_bearing rats in the treatment group,and two rats died at 1 hour and 3 days later; the remaining 5 rats were executed 5 days later.The overall conditions of 5 rats in the treatment group were much better than those in the tumor group(7 rats).Angiogenesis decresaing and hypocellular regions and tumor edema were observed more frequently in the treatment group that those in the tumor group (P<0.05). Conclusion The method of target positioning with computerd tomography will play an improtant pole in further study on stereotactic radiosurgery of brain tumors in rats. |
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