| WU Li,WEN Xiao-ping,HUAN Wei.Treatment of primany hepatic carcinoma with three-dimensional conformal radiation therapy combined with transcatheter arterial chemoembolization[J].Chinese Journal of Radiological Medicine and Protection,2006,26(3):256-258 |
| Treatment of primany hepatic carcinoma with three-dimensional conformal radiation therapy combined with transcatheter arterial chemoembolization |
| Received:February 28, 2006 |
| DOI： |
| KeyWords:Liver neoplasms/radiotherapy Radiotherapy,conformal Liver neoplasms/chemotherapy Embolization,therapeutic Infusion,therapeutic |
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| Abstract:: |
| Objective To evaluate the effects of three-dimensional conformal radiation therapy (3DCRT) combined with transcatheter arterial chemoembolization (TACE) on stage Ⅲ/Ⅳ primary hepatic carcinoma. Methods Eighty cases of stage Ⅲ/Ⅳ primary hepatic carcinoma were randomly divided into two groups: 40 cases treated with three-dimensional conformal radiation therapy combined with transcatheter arterial chemoembolization (3DCRT+TACE group) and 40 cases treated with three-dimensional conformal radiation therapy associated with hepatic arterial infusion chemotherapy (3DCRT+HAI group). Results The response rates were 75% and 45% in 3DCRT+TACE group and 3DCRT+HAI group, respectively; and the difference between the two groups was statistically significant (P<0.05). The 0.5-, 1-, and 2-year local response rates were 93%, 85% and 61% in 3DCRT+TACE group, and 70%, 43% and 33% in 3DCRT+HAI group, respectively; and the difference between the two groups was statistically significant (P<0.05). The difference of distant metastasis rates, 30% in 3DCRT+TACE group and 38% in 3DCRT+HAI group, was not statistically significant (P>0.05), The 0.5-, 1- and 2-year survival rates were 73%, 45% and 28% in 3DCRT+TACE group, and 45%, 25% and 13% in 3DCRT+HAI group, respectively; and the difference between the two groups was statistically significant (P<0.01). The difference of side-effect rates between the two groups was not statistically significant (P>0.05). Conclusion Three-dimensional conformal radiation therapy combined with transcatheter arterial chemoembolization improved prognosis of stage Ⅲ/Ⅳ primary hepatic carcinoma. |
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