| CAI Yong,SU Xing,SUN Shu-fen.Concomitant chemotherapy with radiotherapy in locally advanced pancreatic cancer[J].Chinese Journal of Radiological Medicine and Protection,2006,26(3):253-255 |
| Concomitant chemotherapy with radiotherapy in locally advanced pancreatic cancer |
| Received:June 28, 2005 |
| DOI： |
| KeyWords:Locally advanced pancreatic cancer Radiotherapy Drug therapy Combined modality therapy |
| FundProject: |
| Author Name | Affiliation | E-mail | | CAI Yong | Department of Radiation Oncology, Beijing Cancer Hospital (Institute), Peking University the School Oncology, Beijing 100036, China | caiyong109@sohu.com | | SU Xing | Department of Radiation Oncology, Beijing Cancer Hospital (Institute), Peking University the School Oncology, Beijing 100036, China | | | SUN Shu-fen | 山东威海市立医院肿瘤科 | | | 刘长青 | Department of Radiation Oncology, Beijing Cancer Hospital (Institute), Peking University the School Oncology, Beijing 100036, China | | | 张珊文 | Department of Radiation Oncology, Beijing Cancer Hospital (Institute), Peking University the School Oncology, Beijing 100036, China | | | 徐博 | Department of Radiation Oncology, Beijing Cancer Hospital (Institute), Peking University the School Oncology, Beijing 100036, China | |
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| Abstract:: |
| Objective To evaluate the effect of concurrent chemotherapy with radiotherapy for locally advanced pancreatic cancer (LAPC). Methods Thirty-six cases of LAPC were treated with concurrent chemoradiotherapy from June 1998 to December 2004. The regimens of chemotherapy were as follows: A. 13 patients, 5-Fu 500mg, twice a week; B. 16 patients, 5Fu 500 mg + DDP 300 mg, once a week; C. 7 patients, gemcitabine (GEM) 600 mg, once a week. All the patients were administered such regimens for 37 weeks. Twenty patients were treated with conventional radiation therapy (CRT), the median dose was 50 Gy (ranged from 21 to 60 Gy). Sixteen patients were treated with threedimensional conformal radiation therapy (3D-CRT), the median dose was 60Gy (ranged from 50 to 70 Gy). Results Clinical benefit response (CBR) was 41.6% (15/36 patients). The overall response rates (CR+PR), SD rates, PD rates were 11.1% (4 patients), 66.6% (24 patients), 22.2% (8 patients), respectively. The response rate (CR+PR) of 3D-CRT was 16.6%, which was significantly higher than that in the CRT (5%) (P=0.017). The overall 1- and 2-year survival rates were 33.1%, 11.2%, respectively. The 1-year survival rates were 41.2% and 27.7% in 3D-CRT group (18 patients) and CRT group (20 patients), respectively. The difference between the two groups was statistically significant (P=0.41). 41.6% of the patients showed grade 1-2 hematologic toxicity, 8.3% for the grade 3 hematologic toxicity. Grade 1-2 gastrointestinal toxicity was observed for 52.8% patients, Grade 3 was for 2.8% patients. Conclusion The combined modality treatment is an effective method for LAPC, and the side effects are acceptable. |
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