| WANG Peng,PAN Mian-shun,HUANG Yong.Clincial study on three dimensionally planned boost radiotherapy in combination with chemotherapy for postoperative local recurrence rectal cancer[J].Chinese Journal of Radiological Medicine and Protection,2006,26(3):251-253 |
| Clincial study on three dimensionally planned boost radiotherapy in combination with chemotherapy for postoperative local recurrence rectal cancer |
| Received:October 28, 2005 |
| DOI： |
| KeyWords:Rectal neoplasms Recurrence 3D-comformal radiotherapy |
| FundProject:卫生部科研基金课题(WKJ2005-3-006) |
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| Abstract:: |
| Objective To evaluate the treatment effect of stereotactic radiotherapy (SRT) in combination with chemotherapy for rectal cancer of postoperative local recurrence. Methods Sixty-one rectal cancer cases of postoperative local recurrence were treated with conventional radiotherapy plus 3D-CRT (44 Gy/22 Fx+15-21 Gy/5-7 Fx) in combination with chemotherapy (5-Fu 0.75+CF 200 mg for days 1-5 and days 29-33; Cisplatin 40 mg for days 1-3 and days 29-31). Acute and late radiation syndrome and survival rates were observed, and survival analysis was carried out using Kaplan-Meier method. Results The local control rates were 86.9%, 67.2%, and 37.7%, for the first, second and the third years, respectively. Its corresponding survival rates and tumor-free survival rates in each year were estimated to be 80.3%,62.3%,39.2%, and 79.7%,52.5%, and 31.1%, respectively. The median survival time was estimated to be 24.6 months. Acute radiation syndrome including enterititis, rectitis, and urocystitis were observed, and its degree varied from grade 1 to grade 2. Conclusion Conventional radiotherapy plus three dimensionally radiotherapy in combination with chemotherapy could be considered as an effective and feasible treatment for cancer patients of postoperative local recurrence. |
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