| SONG Liang-wen,SUN Li,LUO Qing_liang.Comparative observation and analysis of pulmonary pathological changes in two cases of extremely severe hematopoietic radiation sickness[J].Chinese Journal of Radiological Medicine and Protection,2006,26(3):210-214 |
| Comparative observation and analysis of pulmonary pathological changes in two cases of extremely severe hematopoietic radiation sickness |
| Received:June 29, 2005 |
| DOI： |
| KeyWords:Irradiation Extremely severe hematopoietic radiation sickness Pulmonary injury Infection Pulmonary fibrosis |
| FundProject:国家自然科学基金资助项目(30570545) |
| Author Name | Affiliation | | SONG Liang-wen | Institute of Radiation Medicine, Beijing 100850, China | | SUN Li | Institute of Radiation Medicine, Beijing 100850, China | | LUO Qing_liang | Institute of Radiation Medicine, Beijing 100850, China | | 彭瑞云 | Institute of Radiation Medicine, Beijing 100850, China | | 黄海潇 | Institute of Radiation Medicine, Beijing 100850, China | | 高亚兵 | Institute of Radiation Medicine, Beijing 100850, China | | 马俊杰 | Institute of Radiation Medicine, Beijing 100850, China | | 张勇 | Institute of Radiation Medicine, Beijing 100850, China | | 尹纪业 | Institute of Radiation Medicine, Beijing 100850, China | | 王晓民 | Institute of Radiation Medicine, Beijing 100850, China | | 李小兵 | 解放军第三七医院病理科 |
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| Abstract:: |
| Objective To comparatively observe the effect of different irradiation doses and survival time on pulmonary pathological changes in extremely severe hematopoietic radiation sickness (ESHRS). Method Samples were taken from different positions of lung tissues in each of the two dead victims, and were fixed by 10% formalin, and then embedded with paraffin. Slice and HE staining were performed, slides were observed under optical microscope and the pathological change was analysis. Results The predominant pathological changes included large areas of necrosis in lung tissue and concomitant extensive infection of aspergillus in the case of ESHRS with slight intestinal type of radiation sickness (No. 107); in another ESHRS case (No. 108), the main pathological alterations included extensive infection of Pneumocystis carinii, filling of pulmonary alveoli with Pneumocystis carinii, thickening of alveolar septum, active proliferation of fibroblast and concomitant formation of collagen fibers. Conclusion Secondary infection of aspergillus or Pneumocystis carinii in lung tissues during the process of rescue and treatment of radiation sickness is directly related to patient's respiratory failure and early death. Pulmonary early fibrosis process can be initiated after ESHRS victim survive for more than two months. |
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