| ZHANG Shu-lan,MA Li-wen,ZHANG Zhao-hui,et al.Clinical observation of multiple metastatic bone cancer by ~153Sm-EDTMP[J].Chinese Journal of Radiological Medicine and Protection,2006,26(2):163-165 |
| Clinical observation of multiple metastatic bone cancer by ~153Sm-EDTMP |
| Received:December 28, 2005 |
| DOI： |
| KeyWords:153Sm-EDTMP Metastatic Bone cancer Life quality Hemapoietic function |
| FundProject: |
| Author Name | Affiliation | | ZHANG Shu-lan | Department of Chemotherapy and Radiation Medicine, Cancer center, The Third Hospital of Peking University, Beijing, 100083, China | | MA Li-wen | Department of Chemotherapy and Radiation Medicine, Cancer center, The Third Hospital of Peking University, Beijing, 100083, China | | ZHANG Zhao-hui | Department of Chemotherapy and Radiation Medicine, Cancer center, The Third Hospital of Peking University, Beijing, 100083, China | | 李惠平 | Department of Chemotherapy and Radiation Medicine, Cancer center, The Third Hospital of Peking University, Beijing, 100083, China | | 贾廷珍 | Department of Chemotherapy and Radiation Medicine, Cancer center, The Third Hospital of Peking University, Beijing, 100083, China |
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| Abstract:: |
| Objective To evaluate the clinical effect and side-effect of hemapoietic function of the patients with metastatic bone cancer treated by 153Sm-EDTMP. Methods 153Sm-EDTMP dose was 0.5-1.5 mCi/kg per time by intravenous, The changes of life quality, cancer size and hemapoietic function before and after treatment with 153Sm-EDTMP were evaluated. Results After treatment with 153Sm-EDTMP, 32.5%(13/40) patients with pain achieved complete response, 50%(20/40) patients had partial response, up progressives were observed in 17.5%(7/40) patients, total effective rate was 82.5%. With Dose<1 mCi, 153Sm-EDTMP administered alone affected more slightly the hemapoiteic fuction of patient's than that with dose >1 mCi, and recovered about four weeks after the treatment. With dose>1 mCi or 153Sm-EDTMP combinated with chmotherapy, the hemapoietic fuction was affected more obviouly. When WBC≤2×109/L, using G-CSF and cord blood to improve WBC level, patients recovered about six weeks after the treatment. Conclusion ① 153Sm-EDTMP treatment of metastatic bone cancer was effective, it can control focuses progress, eliminate metastatic bone focus and improve patient's life quality; ② 153Sm-EDTMP affected the hemapoietic function. With dose≥1 mCi, if 153Sm-EDTMP was administered continuously for more than two times for treatment, whole blood was deceased. ③cord blood can be used to improve hemapoietic function. ; |
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