| QIAO Wen-bo,ZHAO Yan-hui,WANG Chun-bo,et al.Experimental study of the protective effect of ambroxol on radiation-induced pulmonary injury[J].Chinese Journal of Radiological Medicine and Protection,2006,26(2):137-140 |
| Experimental study of the protective effect of ambroxol on radiation-induced pulmonary injury |
| Received:August 04, 2005 |
| DOI： |
| KeyWords:Radiation-induced lung injury Ambroxol Hydroxyproline TGF-β1 |
| FundProject:黑龙江省科技厅攻关资助项目(2001010102900) |
| Author Name | Affiliation | | QIAO Wen-bo | Department of Radiation Oncology, Tumor Hospital of Harbin Medical University, Harbin 150040, China | | ZHAO Yan-hui | Department of Radiation Oncology, Tumor Hospital of Harbin Medical University, Harbin 150040, China | | WANG Chun-bo | Department of Radiation Oncology, Tumor Hospital of Harbin Medical University, Harbin 150040, China | | 王瑞芝 | Department of Radiation Oncology, Tumor Hospital of Harbin Medical University, Harbin 150040, China |
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| Abstract:: |
| Objective To evaluate the protective effect of ambroxol on radiation induced pulmonary injury. Methods 240 BALB/c male mice were divided randomly into control group (C), irridiation alone (SI) and irridiation plus ambroxol (SI+A) groups. The right chests (size:2 cm×2.5 cm) of mice were irridiated by 4 MV linear accelerator for a total doses of 25 Gy,5 Gy/time,one time /day,5 time/week; ambroxol was orally administrered (50 mg·kg-1·d-1) from one week before irridiation until the mice were killed. Hydroxyproline content of lung-irridiated tissue and plasma TGF-β1 level were detected from 1 to 8 months. Results Hydroxyproline content increased starting from3 month, reaching peak at 5 and 6 month. and it was higher is SI group than that in A+SI group; contents in A+SI group was also higher than that of C group in 5-6 months respectively. Cell ultramicro-structure of lung tissue was damaged at different level in 1 and 3 months, a large fribric tissue was even accumulated at 6 months in SI group, while above cases were obviously slight in SI+A group.Conclusions Irridiation could induce the hydroxyproline increase in lung-irridiated tissue, change plasma TGF-β1 level lung tissue, ambroxol may reduce the radiation lung injury. |
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