| ZHAN Hong-wei,YU Xiao-ling,YE Xiao-juan,et al.Multi-factor analysis on events related to hematological toxicity in 153Sm-EDTMP palliative therapy for skeletal metastases[J].Chinese Journal of Radiological Medicine and Protection,2006,26(1):72-74 |
| Multi-factor analysis on events related to hematological toxicity in 153Sm-EDTMP palliative therapy for skeletal metastases |
| Received:November 15, 2005 |
| DOI： |
| KeyWords:153Sm-EDTMP Hematological toxicity Factor analysis Times |
| FundProject: |
| Author Name | Affiliation | | ZHAN Hong-wei | The Second Affiliated Hospital,Zhejiang University College of Medicine,Hangzhou 310009,China | | YU Xiao-ling | 310009 杭州,浙江大学医学院附属第二医院神经外科 | | YE Xiao-juan | The Second Affiliated Hospital,Zhejiang University College of Medicine,Hangzhou 310009,China | | 包承侃 | The Second Affiliated Hospital,Zhejiang University College of Medicine,Hangzhou 310009,China | | 孙达 | The Second Affiliated Hospital,Zhejiang University College of Medicine,Hangzhou 310009,China | | 何刚强 | The Second Affiliated Hospital,Zhejiang University College of Medicine,Hangzhou 310009,China |
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| Abstract:: |
| Objective To investigate the clinical factors related to hematological toxicity induced by intravenous samarium-153 ethylenediaminetetramethylene phosphonic acid( 153Sm-EDTMP) treatment. Methods (A total of) 206 patients with bony metastases treated with 153Sm-EDTMP were retrospectively analyzed.Logistic regression(SPSS 10.0 for Windows) and correlation analysis were used to evaluate the factors concerned. Results Age of the patient,number of bone metastatic lesion,chemotherapy before 153Sm-EDTMP therapy,concurrent radiotherapy and repeat-times of 153Sm-EDTMP treatments were found the individual factors related to hematological toxicity.Chemotherapy before 153Sm-EDTMP,concurrent radiotherapy,medication for normal blood counting and repeat-times of 153Sm-EDTMP treatments were the hematological toxicity factors in multi-factor analysis. Conclusion In 153Sm-EDTMP therapy,several factors were found related to hematological toxicity suggesting more attention be paid to the change of blood cell counting after the palliative therapy. |
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