| SHI Gen-ming,XU Qin,YANG Yi-li,et al.Iufluence of surgical or propylthiouracil pretreatment on the efficacy of iodine-131 therapy in hyperthyroidism[J].Chinese Journal of Radiological Medicine and Protection,2006,26(1):68-70 |
| Iufluence of surgical or propylthiouracil pretreatment on the efficacy of iodine-131 therapy in hyperthyroidism |
| Received:August 08, 2005 |
| DOI： |
| KeyWords:Hyperthyroidism Propylthiouracil Surgical treatment Iodine-131 |
| FundProject:浙江省教育厅基金资助项目(20030237) |
| Author Name | Affiliation | E-mail | | SHI Gen-ming | The First Affiliated Hospital,College of Medical Sciences,Zhejiang University,Hangzhou 310003,China | xuqing8@hotmail.com | | XU Qin | The First Affiliated Hospital,College of Medical Sciences,Zhejiang University,Hangzhou 310003,China | | | YANG Yi-li | The First Affiliated Hospital,College of Medical Sciences,Zhejiang University,Hangzhou 310003,China | | | 叶安方 | The First Affiliated Hospital,College of Medical Sciences,Zhejiang University,Hangzhou 310003,China | | | 朱诚忆 | The First Affiliated Hospital,College of Medical Sciences,Zhejiang University,Hangzhou 310003,China | |
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| Abstract:: |
| Objective To investigate the influence of surgical or propylthiouracil(PTU) pretreatment on the efficacy of radioactive iodine therapy in hyperthyroidism. Methods A group(group 1) of 41 hyperthyroidism patients relapsed after surgery were treated with 131I in our department from 2003 through 2004. During that period,another group(group 2) of 41 cases were selected randomly from patients untreated either surgically or chemically before oral administration of 131I,and a third group(group 3) of 41 cases were selected randomly from those pretreated only with PTU.We analysed the results of these three groups of patients after followed_up for 3 and 6 months separately after 131I therapy. Results Approximately 90.24%(37/41 cases) and 92.68%(38/41 cases) of patients in group 2 without any pretreatment were cured 3 months and 6 months after 131I treatment,respectively,and 9.76%(4/41 cases) and 7.32%(3/41 cases) of them did not respond to 131I treatment.About 43.90%(18/41 cases) and 53.66%(22/41 cases) of patients pretreated with PTU(group 3)were cured at 3 and 6 months,respectively,and approximately 56.10%(23/41 cases) and 46.34%(19/41 cases) of this group patients did not respond to 131I treatment at 3 and 6 months,respectively(P<0.01) compared with the un_pretreated group.About 68.29%(28/41 cases) and 70.73%(29/41 cases) of relapsed patients after surgery(group 1) were cured at 3 and 6 months after 131I treatment,respectively,and 31.71%(13/41) and 29.27%(12/41) of them did not respond to 131I treatment(P<0.05) as compared with the unpretreated group. Conclusion (Surgery or PTU) pretreatment of hyperthyroidism patient before 131I treatment can affect the efficacy of 131I therapy,resulting in reduction of the cure rate. |
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