| QIU Xiao-zhong,PIAO Ying-jie,YU lei,et al.Study on γ-ray induced mitochondrial autophagy and regeneration of liver cells in rats[J].Chinese Journal of Radiological Medicine and Protection,2006,26(1):50-52 |
| Study on γ-ray induced mitochondrial autophagy and regeneration of liver cells in rats |
| Received:July 08, 2005 |
| DOI： |
| KeyWords:γ-ray irradiation Mitochondrial autophagy Apoptosis Mitochondrial regeneration |
| FundProject:广东省专项课题基金资助项目(A302020401);广东省科技攻关基金资助项目(2KM05503S);广州市科技攻关基金资助项目(2002Z1-E0037) |
| Author Name | Affiliation | E-mail | | QIU Xiao-zhong | Key Laboratory of Tissue Construction and Examination,Department of Anatomy Southern Medical University, Guangzhou 510515,China | qqiuxzh@yahoo.com.cn | | PIAO Ying-jie | Key Laboratory of Tissue Construction and Examination,Department of Anatomy Southern Medical University, Guangzhou 510515,China | | | YU lei | Key Laboratory of Tissue Construction and Examination,Department of Anatomy Southern Medical University, Guangzhou 510515,China | | | 廖华 | Key Laboratory of Tissue Construction and Examination,Department of Anatomy Southern Medical University, Guangzhou 510515,China | | | 秦建强 | Key Laboratory of Tissue Construction and Examination,Department of Anatomy Southern Medical University, Guangzhou 510515,China | | | 杨俊 | Key Laboratory of Tissue Construction and Examination,Department of Anatomy Southern Medical University, Guangzhou 510515,China | | | 焦培峰 | Key Laboratory of Tissue Construction and Examination,Department of Anatomy Southern Medical University, Guangzhou 510515,China | | | 欧阳钧 | Key Laboratory of Tissue Construction and Examination,Department of Anatomy Southern Medical University, Guangzhou 510515,China | |
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| Abstract:: |
| Objective To explore the role of mitochondrial autophagy in wound healing.Methods(Damages of) liver cells in rats after γ-ray irradiation with a total dose of 8 Gy were investigated.The relationship between mitochondrial autophagy and repair of liver cells was observed ultrastructurally.Apoptosis-related DNA fragment and mitochondrial RNA levels were analyzed.Results Most of the damaged mitochondria were removed through mitochondrial autophagy.Apoptosis-related DNA fragment analysis implied that,accompanied with reduction of mitochondrial autophagy,the amount of cellular apoptosis was decreased during wound healing.Wound healing was related to mitochondrial regeneration after mitochondrial autophagy.Conclusion Mitochondrial autophagy may release some molecular signals for wound healing so as to accelerate sufficiently the regeneration of newly formed mitochondria. |
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