GAO Hong,LIU Lu,TENG Gao-jun,et al.Clinical study on treatment of refractory solid tumor by intervention with 32P colloids or microspheres[J].Chinese Journal of Radiological Medicine and Protection,2006,26(1):43-47 |
Clinical study on treatment of refractory solid tumor by intervention with 32P colloids or microspheres |
Received:December 18, 2005 |
DOI: |
KeyWords:Refractory solid tumor Interventional therapy Phosphorus radioactive nuclide |
FundProject:铁道部科研基金资助项目(J1998Z021);江苏省卫生厅科研基金资助项目(H200117) |
Author Name | Affiliation | GAO Hong | Tumor Treatment Center,Beijing Shijitan Hospital,Beijing 100038,China | LIU Lu | Tumor Treatment Center,Beijing Shijitan Hospital,Beijing 100038,China | TENG Gao-jun | 东南大学附属中大医院介入放射科 | 封国生 | Tumor Treatment Center,Beijing Shijitan Hospital,Beijing 100038,China | 张士东 | Tumor Treatment Center,Beijing Shijitan Hospital,Beijing 100038,China | 童冠圣 | Tumor Treatment Center,Beijing Shijitan Hospital,Beijing 100038,China | 郭金和 | 东南大学附属中大医院介入放射科 | 刘龙 | Tumor Treatment Center,Beijing Shijitan Hospital,Beijing 100038,China | 高乃荣 | 东南大学附属中大医院肝胆外科 |
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Abstract:: |
Objective To study the therapeutic effectiveness of 32 colloids or microspheres in treatment of the solid tumors. Methods Thirty patients with refractory solid tumor served as the objects of investigation.After the tumor size was defined by CT scan, 32 colloids or microspheres(259-685 MBq) were administered through intra-arterial intervention or injected into the tumor proper under direct vision during operation or through per cutaneous injection under the guidance of CT or X-ray.The tumor inhibiting rate,side effect and surviving time were observed through γ camera,X-ray plan film,CT,ultrasonography and hematological assay. Results(The tumor growth) was prominently inhibited after the intra-tumoral injection of 32 preparations.The average surviving time of the patients was 33 months,the tumor-inhibiting rate was 96.6%.Complete inhibition was shown in 16 cases(53.3%) and partial inhibition in 13 cases(43.3%).The longest survivor,one patient with right lobe hepatic carcinoma,has been living up to now for at least 94 months.Prominent side effects did not occur but one patient with radiation lung development died from hepatic failure,and the results of pathological examination revealed intra-tumoral necrosis,highly fibrosed tumor mass and an integrated capsule as the outmost layer. Conclusion 32 colloids or microspheres are the ideal radioactive agents for the treatment of refractory solid tumors.Further improving the clinical therapeutic effectiveness through rational solid selection of indications and/or procedures for administration of these agents is strictly required. |
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