| SONG Liang-wen,SUN Li,LUO Qing-liang,et al.Exploration of initiation mechanism of early pulmonary fibrosis in extremely severe hematopoietic type of radiation sickness[J].Chinese Journal of Radiological Medicine and Protection,2006,26(1):35-38 |
| Exploration of initiation mechanism of early pulmonary fibrosis in extremely severe hematopoietic type of radiation sickness |
| Received:September 30, 2005 |
| DOI： |
| KeyWords:Pulmonary fibrosis Growth factor Collagen Hematopoietic type of radiation sickness |
| FundProject:国家自然科学基金资助项目(30570545) |
| Author Name | Affiliation | | SONG Liang-wen | Beijing Institute of Radiation Medicine,Beijing 100850,China | | SUN Li | Beijing Institute of Radiation Medicine,Beijing 100850,China | | LUO Qing-liang | Beijing Institute of Radiation Medicine,Beijing 100850,China | | 马俊杰 | Beijing Institute of Radiation Medicine,Beijing 100850,China | | 张勇 | Beijing Institute of Radiation Medicine,Beijing 100850,China | | 尹纪业 | Beijing Institute of Radiation Medicine,Beijing 100850,China | | 李杨 | Beijing Institute of Radiation Medicine,Beijing 100850,China | | 李小兵 | 100850 北京解放军307医院病理科 |
|
| Hits: 3230 |
| Download times: 2083 |
| Abstract:: |
| Objective To explore pathogenetic mechanism of early pulmonary fibrosis in extremely severe hematopoietic type of radiation sickness and its relation to irradiation dose and surviving time of the patient. Methods Autopsy of two cases of radiation sickness was performed and conventional histopathological sections of lung tissue were prepared,which were stained immunohistochemically for TGFβ,α-SMA,precollagen Ⅳ,MMP-9 and Sirius red. Results In one case,the TGFβ_positive signal was located in alveolar macrophages,α-SMA signal appeared in smooth muscle cells and macrophages,weak procollagen Ⅳ and MMP-9 signals displayed in a small number of type Ⅱ epithelial cell.In another case,the TGFβ signal was located in proliferating fibroblasts,α-SMA signal displayed in myofibroblasts,a lot of collagen Ⅰ and Ⅲ signals appeared in thickened alveolar septa,and a strong positive signals of procollagen Ⅳ and MMP-9 could be seen in type Ⅱ epithelal cell. Conclusion TGF-β can be expressed in lung tissue of patients with hematopoietic type of radiation sickness and promote fibroblasts to transform into myofibroblasts.Collagen I and Ⅲ can be produced at alveolar septum,which extent is in inverse ratio to radiation dose and in direct ratio to surviving time of the patient. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
|
|
|
