| LIU Li,DING Qian,YAO Jun-xia,et al.Influence of radiotherapy on CD4+CD25high regulatory cells in peripheral blood of NPC patients[J].Chinese Journal of Radiological Medicine and Protection,2006,26(1):31-34 |
| Influence of radiotherapy on CD4+CD25high regulatory cells in peripheral blood of NPC patients |
| Received:February 28, 2005 |
| DOI： |
| KeyWords:Nasopharyngeal carcinoma(NPC) Radiotherapy CD4+CD25high regulatory T cells(Tr cells) Flow cytometry |
| FundProject:国家973重点课题资助项目(2001CB5101);国家杰出青年基金资助项目(30225038) |
| Author Name | Affiliation | E-mail | | LIU Li | Cancer Center and Stem Cell Center,Union Hospital,Huazhong University of Science and Technology,Wuhan 430023,China | sa2huang@hotmail.com | | DING Qian | Cancer Center and Stem Cell Center,Union Hospital,Huazhong University of Science and Technology,Wuhan 430023,China | | | YAO Jun-xia | 430022 武汉,协和医院干细胞中心 | | | 宋颖秋 | Cancer Center and Stem Cell Center,Union Hospital,Huazhong University of Science and Technology,Wuhan 430023,China | | | 曹如波 | Cancer Center and Stem Cell Center,Union Hospital,Huazhong University of Science and Technology,Wuhan 430023,China | | | 黄士昂 | 430022 武汉,协和医院干细胞中心 | |
|
| Hits: 3640 |
| Download times: 2658 |
| Abstract:: |
| Objective The current study was designed to investigate the changes in peripheralCD4+CD25high regulatory T(CD4+CD25high Tr) cells in patients with nasopharyngeal carcinoma(NPC) and the influence of radiotherapy on immunity function.Methods The peripheral blood was collected from 36 patients with NPC and 30 healthy controls.By using monoclonal antibodies,the blood samples were evaluated with flow cytometry for lymphocyte subsets and Tr cells. Results The ratio of CD4+/CD8+ in the NPC group was not significantly less than that in the healthy controls(P>0.05),but the prevalence of the CD4+CD25high Tr cells was significantly higher than that of the healthy group [(2.76±1.06)% versus(2.06±0.98)%,P<0.05].At the end of radiotherapy,the proportion of CD4+CD25high Tr cells was higher than before it [(4.88±1.02)%,P<0.05]. Conclusion The relative increase in CD4+CD25high Tr cells in peripheral blood of NPC patients with or without radiotherapy was significantly higher than those in healthy controls,which may be related to immunosupression and tumor progression in such patients.This finding suggests that CD4+CD25high Tr cells in peripheral blood of NPC patients can be a useful index for monitoring the immunity function. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
|
|
|
