| WANG Jun-jie,RAN Wei-qiang,YUAN Hui-shu,et al.Implantation of iodine-125 seed for head and neck carcinoma[J].Chinese Journal of Radiological Medicine and Protection,2006,26(1):23-26 |
| Implantation of iodine-125 seed for head and neck carcinoma |
| Received:September 28, 2005 |
| DOI： |
| KeyWords:125I-seeds Head and neck cancer CT |
| FundProject: |
| Author Name | Affiliation | | WANG Jun-jie | The Cancer Center,Third Hospital of Peking University,Beijing 100083,China | | RAN Wei-qiang | The Cancer Center,Third Hospital of Peking University,Beijing 100083,China | | YUAN Hui-shu | The Cancer Center,Third Hospital of Peking University,Beijing 100083,China | | 姜玉良 | The Cancer Center,Third Hospital of Peking University,Beijing 100083,China | | 刘江平 | The Cancer Center,Third Hospital of Peking University,Beijing 100083,China | | 李金娜 | The Cancer Center,Third Hospital of Peking University,Beijing 100083,China | | 姜伟娟 | The Cancer Center,Third Hospital of Peking University,Beijing 100083,China |
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| Abstract:: |
| Objective To investigate the technological feasibility,efficacy and morbidity of 125I-seed implantation for head and neck cancer. Methods Forty patients with head and neck cancer were treated with 125I-seed intersitial brachytherapy guided by ultrasound or CT.Among them thirty-six patients were performed under local anesthesia and four were under general anesthesia.Thirty-six patients were treated with 125I-seed implantation under ultrasound guidance and four cases under CT guidance.Seed needles were implanted in parallel with each other,1-1.5 cm apart.Mick applicator was used to each needle to implant seed.The radioactive activity ranged 0.40-0.70 mCi,and the matched peripheral doses were 90-145 Gy.The mean number of 125I-seed was 3-84.Five cases received external beam irradiation one week after seed implantation,and the total doses were 45-50 Gy(200 cGy/f).All the cases were examined by X-ray or CT after implantation for quality evaluation and by routine chest X ray within twenty-four to forty-eight hours after seed implantation. Results These patients were followed-up for 3-33 months.In 10 tongue carcinoma patients,complete response was shown in 3 cases,partial response in three cases,no change in three cases and progressive disease in one case.The local control rate was 60%,the median survival time was 11 monthes,and the one-year and two year survival rates were 87.50% and 35%,respectively.In 14 patients with recurrent cancer of head and neck the local control rate was 76.47%,the one-year and two-year survival rates were 66.08% and 24%,respectively,and the median survival time was 9 months.In 16 patients with metastatic cancer of head and neck the local control rate was 95.23%,the one-year and two-year survival rates were 54.55% and 32.73%,and the median survival time was 9 months.One seed migrated to the maxilla and loss of seeds happened in two cases,but there was no clinically related mobidity. Conclusion 125I-seed implantation for recurrent or metastatic head and neck cancer under guidance of ultrasound or CT is safe,minimal invasive,with low morbidity and high efficacy,especially for recurrent and matastatic cancer of head and neck after surgery or radiotherapy. |
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