| KE Xiao-yan,JIA Ting-zhen,WANG Ji-jun,et al.Clinical investigation of iatrogenic acute radiation sickness[J].Chinese Journal of Radiological Medicine and Protection,2006,26(1):15-19 |
| Clinical investigation of iatrogenic acute radiation sickness |
| Received:September 28, 2005 |
| DOI： |
| KeyWords:Iatrogenic acute radiation syndrome Stem cells transplantation Total body irradiation rhG-CSF |
| FundProject: |
| Author Name | Affiliation | E-mail | | KE Xiao-yan | Department of Hematology,Department of Chemotherapy and Radiotherapy,Third Hospital of Peking University,Beijing 100083,China | xiaoyand@yahoo.com | | JIA Ting-zhen | 100083 北京大学第三医院肿瘤化疗放射病科 | | | WANG Ji-jun | Department of Hematology,Department of Chemotherapy and Radiotherapy,Third Hospital of Peking University,Beijing 100083,China | | | 马兰 | Department of Hematology,Department of Chemotherapy and Radiotherapy,Third Hospital of Peking University,Beijing 100083,China | | | 肖辉 | Department of Hematology,Department of Chemotherapy and Radiotherapy,Third Hospital of Peking University,Beijing 100083,China | | | 王良绪 | Department of Hematology,Department of Chemotherapy and Radiotherapy,Third Hospital of Peking University,Beijing 100083,China | |
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| Abstract:: |
| Objective To accumulate clinical experience for treatment of accidental acute radiation sickness(ARS) by observation of ARS induced by medical treatment. Methods To observe the changes of peripheral blood indexes,body temperature and clinical symptoms of 41 cases who were clinically irradiated with high dose irradiation(TBI or TLI) before autologous peripheral blood stem cell transplantation(auto-PBSCT).All data were statistically analyzed. Results After irradiation,peripheral WBC and PLT counts began to decrease,and reached their lowest levels at days 10 and 13 separately.They returned to the normal levels at days 18 and 17,respectively.Hb only decreased mildly.The hematopoietic reconstruction time was significantly different between the group of using G-CSF and the group without using it.The number of MNC infused and the time of hematopoietic reconstitution bore negative correlation.The side effects of high dose irradiation included vomiting,debilitation,parotid gland megaly,dental ulcer,hepatic injury and skin injury.In addition,25.6% of the cases got fever after irradiation.The incidence of infection at neutropenia phase was 63.7%,but most of them were mild.There was no significant injury of cardiac and renal functions.Most cases could tide over the myelosuppression phase smoothly without crisis of ARS. Conclusion Treatment with G-CSF can reduce the time span for bone marrow reconstruction significantly.Infusion of sufficient number of MNC is critical for bone marrow reconstruction.Comprehensive environmental protection and combined antibiotics treatment are the key points for patients to overcome neutropenia successfully during PBSCT. |
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