| LIU Ya-jie,WANG Shu-bin,GUO Yi-ling.Clinical study of 89Sr therapy with radiosensitization by nicotinamide and carbogen in multiple bone metastasis of malignant neoplasms[J].Chinese Journal of Radiological Medicine and Protection,2005,25(6):545-547 |
| Clinical study of 89Sr therapy with radiosensitization by nicotinamide and carbogen in multiple bone metastasis of malignant neoplasms |
| Received:January 04, 2005 |
| DOI： |
| KeyWords:Malignant neoplasms Bone metastasis 89Sr Nicotinamid Carbogen |
| FundProject:广东省自然科学基金资助项目(000372) |
| Author Name | Affiliation | E-mail | | LIU Ya-jie | Department of Radiation Oncology, Department of Nuclear Medicine, Shenzhen People’s Hospital &
Second Hospital of Medical College, Jinan University. Shenzhen 518020, China | yingnanzh@yahoo.com.cn | | WANG Shu-bin | Department of Radiation Oncology, Department of Nuclear Medicine, Shenzhen People’s Hospital &
Second Hospital of Medical College, Jinan University. Shenzhen 518020, China | | | GUO Yi-ling | 518020 深圳, 暨南大学医学院附属第二医院暨深圳市人民医院核医学科 | | | 陈佐伟 | Department of Radiation Oncology, Department of Nuclear Medicine, Shenzhen People’s Hospital &
Second Hospital of Medical College, Jinan University. Shenzhen 518020, China | | | 张英男 | 518020 深圳, 暨南大学医学院附属第二医院暨深圳市人民医院核医学科 | |
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| Abstract:: |
| Objective To evaluate the curative effect and side effects of 89Sr therapy with radiosensitization by nicotinamide and carbogen in multiple bone metastasis of malignant neoplasms. Methods Ninty-seven patients were divided into 4 groups respectively: group A, 89Sr + nicotinamide + carbogen（24 patients）; group B, 89Sr + nicotinamide（22 patients）; group C, 89Sr + carbogen（25 patients）; group D, 89Sr,（26 patients）. 89SrCl was intravenously injected at a dose of 1.48-2.22 MBq/kg. Nicotinamide was taken orally 1 hour before 89SrCl injection, 6 g/day, tid, d1-d5. Aspiration of carbogen（95%O2+5%CO2） gases,6 L/min,10 minuts, qd,d1-d5. Results The effective rate of pain control and QOL improvement in A group were higher than in groups B, C and D （91.7% VS 77.3%,76.0% and 69.2%,P=0.048 ）. The lesions assessed by SPECT imaging in every group was not significantly different at three months after treatment.Ⅰ to Ⅱ degree toxic effect on bone marrow appeared in every group and there were no significantly inter-group differences. Conclusions Combinative therapy using 89Sr + nicotinamide + carbogen is more effective to treat multiple metastatic bone pain and for improvement of QOL. The side effects are not increased.; |
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