| JU Yang,LUO Qin,DANG Yue-lan.Protective effect of Acanthopanax giraldii Harms polysaccharides on radiation injury in mice and its mechanism[J].Chinese Journal of Radiological Medicine and Protection,2005,25(6):533-536 |
| Protective effect of Acanthopanax giraldii Harms polysaccharides on radiation injury in mice and its mechanism |
| Received:December 22, 2004 |
| DOI： |
| KeyWords:Acanthopanax giraldii Harms polysaccharides Radiation injury Blood cell counts Enzyme activity Nucleic acid Antioxidation |
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| Abstract:: |
| Objective To study the protective effect of Acanthopanax giraldii Harms polysaccharides(AGP)on radiation injury in mice and its mechanism. Methods The mice were treated with ip injection of AGP(125-250 mg/kg) and exposure to whole-body irradiation with 60Co γ-rays.The white blood cell(WBC),blood platelets(PLT), reticulocyte counts, the number of nucleated bone marrow cell(NNBMC), the content of MDA in the liver and serum,the content of DNA and RNA in the liver and spleen, and activities of ALT,AST,SOD,GSH-PX in the serum and blood were measured. Results After irradiation, the general status of the mice was changed as showed by hair deprivation, body weight reduction, blood spots appearance on the tail,and so on. The numbers of WBC, PLT, reticulocytes and NNBMC all reduced remarkablely. MDA contents and activities of ALT,AST increased obviously, and DNA,RNA contents and activities of SOD, GSH-PX decreased evidently afterir radiation. AGP could accelerate restoration of all these indexs. Conclusion AGP has protective effects on irradiated mice, the mechanism of which might be related with antioxidation. |
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