| MENG Li,PENG Rui-Yun,GAO Ya-Bing,et al.Effects of HPM irradiation on expression of GR in hypothalamus and pituitary gland of rats[J].Chinese Journal of Radiological Medicine and Protection,2005,25(5):480-481,484 |
| Effects of HPM irradiation on expression of GR in hypothalamus and pituitary gland of rats |
| Received:October 25, 2004 |
| DOI： |
| KeyWords:HPM Rat Hypothalamus Pituitary Glucocorticoid receptor |
| FundProject: |
| Author Name | Affiliation | E-mail | | MENG Li | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | pengry@nic.bmi.ac.cn | | PENG Rui-Yun | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | GAO Ya-Bing | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | 马俊杰 | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | 王水明 | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | 胡文华 | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | 王德文 | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | 苏镇涛 | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | |
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| Abstract:: |
| Objective To explore the expression and significance of glucocorticoid receptor (GR) in hypothalamus and pituitary gland of rats after high power microwave(HPM) exposure. Methods A total of 130 male Wistar rats were sacrificed at 6 h, 1 d, 3 d, 7 d, 14 d, 28 d and 3 m after whole body irradiation by 2-90 mW/cm2 HPM and their hypothalamus and pituitary gland were collected. The changes of GR in the two tissues after HPM exposure were investigated by means of immunohistochemical staining and image analysis. Results The expression of GR in hypothalamus was decreased after HPM exposure. The level of GR in the group of 10 mW/cm2 was significantly lower(P<0.05)than that in the sham exposure group at 6 h and 1 d, and revealed a tendency towards recovery after 7 d. GR in the 50 mW/cm2 group was significantly lower(P<0.05)on 1 d. The expression of GR in anterior pituitary was increased after HPM exposure. GR in the 10 mW/cm2 group was significantly higher(P<0.01)at 6 h and revealed a tendency towards recovery after 7 d. GR in the 50 mW/cm2 group was significantly higher (P<0.01)on 1 d and 3 d after HPM exposure. Conclusion The expression of GR in hypothalamus was decreased while that in the anterior pituitary was increased after HPM exposure.The refore,the negative feedback of hypothalamic-pituitary-adrenal (HPA) axis was upset and the changes of GR is involved in the pathophysiological course of HPA. |
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