| DU Yan-rong,CHEN Fang,LI Fang.Stability and dosimetry of 99mTc-RBC prepared by kit method in healthy volunteers[J].Chinese Journal of Radiological Medicine and Protection,2005,25(5):456-458 |
| Stability and dosimetry of 99mTc-RBC prepared by kit method in healthy volunteers |
| Received:October 18, 2004 |
| DOI： |
| KeyWords:RBC kit 99mT-RBC In vivo stability Absorbed radiation dose |
| FundProject: |
| Author Name | Affiliation | | DU Yan-rong | Department of Nuclear Medicine, PUMC Hospital, PUMC and CAMS, Beijing 100730, China | | CHEN Fang | Department of Nuclear Medicine, PUMC Hospital, PUMC and CAMS, Beijing 100730, China | | LI Fang | Department of Nuclear Medicine, PUMC Hospital, PUMC and CAMS, Beijing 100730, China | | 陈黎波 | Department of Nuclear Medicine, PUMC Hospital, PUMC and CAMS, Beijing 100730, China | | 龙明清 | Department of Nuclear Medicine, PUMC Hospital, PUMC and CAMS, Beijing 100730, China |
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| Abstract:: |
| Objective To study the in vivo stability of and absorbed radiation dose from 99mT-RBC, prepared using RBC kit made in our laboratory. Methods Four healthy volunteers were studied with 99mT-RBC prepared by kit method. Whole body images were acquired at 5 min, 1, 2.5, 4, 8 and 24 hours after intravenous injection of 481-555 MBq 99mT-RBC. Biodistribution analysis was performed in regions of interest (ROI). The absorbed radiation doses were calculated using the MIRDOSE3.0 analysis program and the time-related activity curves for different organs were used for the residence time calculations. Results 99mT-RBC prepared by kit method was stable in vivo. The quality of blood pool imaging from 5 min to 8 h in healthy volunteers was satisfactory. The absorbed radiation dose was lower than the permissible value. Conclusion 99mT-RBC prepared by kit method is very suitable for clinical application. |
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