| WANG Jun-jie,XIU Dian-rong,RAN Wei-qiang.Iodine-125 seed implantation for unresectable pancreatic carcinoma guided by intraoperative ultrasound[J].Chinese Journal of Radiological Medicine and Protection,2005,25(5):441-443 |
| Iodine-125 seed implantation for unresectable pancreatic carcinoma guided by intraoperative ultrasound |
| Received:February 25, 2005 |
| DOI： |
| KeyWords:125Ⅰ seed Interstitial implantation Pancreatic carcinoma |
| FundProject: |
| Author Name | Affiliation | | WANG Jun-jie | Cancer Center, The 3 rd Hospital of Peking University, Beijing 100083, China | | XIU Dian-rong | Cancer Center, The 3 rd Hospital of Peking University, Beijing 100083, China | | RAN Wei-qiang | Cancer Center, The 3 rd Hospital of Peking University, Beijing 100083, China | | 白静 | Cancer Center, The 3 rd Hospital of Peking University, Beijing 100083, China | | 朱丽红 | Cancer Center, The 3 rd Hospital of Peking University, Beijing 100083, China | | 刘江平 | Cancer Center, The 3 rd Hospital of Peking University, Beijing 100083, China |
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| Abstract:: |
| Objective To investigate the surgical technique,efficacy and side effects of 125Ⅰ seed interstitial implantation for pancreatic carcinoma. Methods A total of 22 patients with biopsy proven unresectable adenocarcinoma of pancreas were treated with 125Ⅰ implants during laparotomy. Of them 11 patients were treated previously by a combination of bypass surgery. The stent was implanted in 2 cases 2 weeks before and 4 weeks after seed implantation. Seed needles were implanted parallelly to each other,with 1-1.5 cm apart. Mick applicator was being connected to each needle to implant seed. The radioactive activity ranged 0.40-0.70 mCi,the matched peripheral doses were 65-145 Gy. The mean number of 125Ⅰ seed was 11-78. Five cases received external beam irradiation with 3D-CRT, the doses were 39-70 Gy and 5 patients received 2 cycle of gemcitabine chemotherapy at 1000 mg/m2 on dl and d8. Results Pain was completely relieved in 12 cases,partially relieved in 2 cases,and no response was noted in one case, so the response rate was 93.33%. The median time was 2-3 d.Altogethe 27.27% of the cases died from local recurrence of pancreatic carcinoma and 50% from metastasis. The median survival time in these patients was 6 months,with a 2-year survival rate of 9.09%. The seed immigrated to liver in 3 cases.There were no serious side effects such as infection,pancreatitis,pancreatic fistula,etc. Conclusion Radioactive seed implantation was safe,high local control,mini-damage,satisfactory palliation of pain and without significant complications. |
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