| ZHAN Hong-wei,YE Xiao-juan,BAO Cheng-kan.Study on improvement of tumor hypoxia and 32P-colloid interstitial treatment effect by lasting inhalation of carbogen[J].Chinese Journal of Radiological Medicine and Protection,2005,25(5):437-440 |
| Study on improvement of tumor hypoxia and 32P-colloid interstitial treatment effect by lasting inhalation of carbogen |
| Received:January 16, 2005 |
| DOI： |
| KeyWords:Carbogen Hypoxia Murine tumor 32P-colloid interstitial treatment Effect |
| FundProject: |
| Author Name | Affiliation | | ZHAN Hong-wei | Department of Nuclear Medicine, Second Affiliated Hospital, College of Medicine Zhejiang University, Hangzhou 310009, China | | YE Xiao-juan | Department of Nuclear Medicine, Second Affiliated Hospital, College of Medicine Zhejiang University, Hangzhou 310009, China | | BAO Cheng-kan | Department of Nuclear Medicine, Second Affiliated Hospital, College of Medicine Zhejiang University, Hangzhou 310009, China | | 孙达 | Department of Nuclear Medicine, Second Affiliated Hospital, College of Medicine Zhejiang University, Hangzhou 310009, China | | 何刚强 | Department of Nuclear Medicine, Second Affiliated Hospital, College of Medicine Zhejiang University, Hangzhou 310009, China | | 张宏 | Department of Nuclear Medicine, Second Affiliated Hospital, College of Medicine Zhejiang University, Hangzhou 310009, China |
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| Abstract:: |
| Objective To study the safety and improvement in tumor hypoxia and the 32P-colloid interstitial treatment effect with lasting carbogen-inhaling in murine tumor models. Methods 1. The 99mT-HL91 SPECT imaging was performed in 10 S180 tumor-bearing mice before and after carbogen inhalation for 2 hours; 2. Twenty normal BALB/c mice were divided into an air-group and a carbogen-group, in which carbogen was inhaled by mice 2 hours per day for 24 days. The activity body weight were observed, and pathologic examination of important organs was taken; 3. Forty mice bearing S180 tumor were divided into four groups: untreated air-inhaling group, untreated carbogen-group, 32P-treated air-inhaling group, 32P-treated carbogen-inhaling group. The volume of tumors and tumor inhibition curves were measured and compared in all mice,and the tumor inhibition ratio was calculated.Results 1.The T/NT of 99mT-HL91 before and after carbogen inhalation was 1.872± 0.391 and 1.354± 0.189, respectively (t=4.476, P<0.01); 2. The tumor volume was not different between mice of untreated air-inhaling group and untreated carbogen-inhaling group; The tumor inhibition ratio was 66.01% and 69.43% respectively in the mice of 32P-treated, air-inhaling group and 32P-treated, carbogen-inhaling group on day 12 after 32P-colloid interstitial treatment, whereas on day 24 the tumor volume was 2.728± 0.469 cm3 and (2.237± 0.603) cm3 (t= 2.128, P< 0.05) and the tumor mass was 2.437± 0.447 and (1.965± 0.538)g (t= 2.134, P< 0.05); 3. There were no differences in the activity, body weight between untreated air-inhaling mice and untreated carbogen-inhaling mice. No abnormal pathologic changes of important organs were found in untreated carbogen inhalation mice. Conclusion Long-term carbogen inhalation could significantly improve tumor hypoxia and 32P-celloid interstitial treatment effect, and no toxicity was observed in mice. |
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