| CHEN Jun-qiang,CHEN Ming-qiang,LI Yun-ying.Toxic reactions after late course accelerated hyperfractionated radiotherapy plus concurrent chemotherapy for esophageal carcinoma[J].Chinese Journal of Radiological Medicine and Protection,2005,25(4):356-358 |
| Toxic reactions after late course accelerated hyperfractionated radiotherapy plus concurrent chemotherapy for esophageal carcinoma |
| Received:January 18, 2005 |
| DOI： |
| KeyWords:Esophageal carcinoma Radiotherapy Accelerated hyperfractionation Toxic reactions |
| FundProject: |
| Author Name | Affiliation | | CHEN Jun-qiang | Department of Radiation Oncology, Cancer Hospital of Fujian Province, Fuzhou 350014, China | | CHEN Ming-qiang | Department of Radiation Oncology, Cancer Hospital of Fujian Province, Fuzhou 350014, China | | LI Yun-ying | Department of Radiation Oncology, Cancer Hospital of Fujian Province, Fuzhou 350014, China | | 潘建基 | Department of Radiation Oncology, Cancer Hospital of Fujian Province, Fuzhou 350014, China | | 林宇邵 | Department of Radiation Oncology, Cancer Hospital of Fujian Province, Fuzhou 350014, China | | 凌东 | Department of Radiation Oncology, Cancer Hospital of Fujian Province, Fuzhou 350014, China |
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| Abstract:: |
| Objective To assess the toxic reactions after late course accelerated hyperfractionated radiotherapy(LAHF) plus concurrent chemotherapy for esophageal carcinoma. Methods Altogether 80 patients with advanced esophageal squamous carcinoma were selected for this study. Eligible criteria included the patients with lesion less than 12 cm in length, without distant metastases. Patients were equally randomized into LAHF and CF groups. The characteristics of these two groups of patients had no statistical significant difference. For the CF group, 70 Gy were given in 35 fractions over 49 days. For the LAHF group, radiotherapy were divided into two phases: 40 Gy in the first phase with fraction dose 2 Gy per day; 27 Gy during the second phase with 1.5 Gy per fraction and two fractions a day. The total dose in the LAHF group was 67 Gy in 38 fractions over 42 days. The chemotherapy was delivered concurrently with FUDR 500 mg/m2 and cisplatin 20 mg/m2 given twice weekly for 3 weeks. Results Acute esophagitis occurred in 100% and 87.5% of the patients in the LAHF group and the CF group, respectively. Grade 3/4 in LAHF group was 35%, being higher and longer than that in CF group (15%). Although 5.6% of the patients in the combined group developed grade 5 acute toxicity, none was noted in the LAHF alone group. The hematopoietic, gastriointestinal and pulmonary toxicities were not significantly different between LAHF group and CF group(P>0.05).Three patients in LAHF group and 1 patient in CF group discontinued radiotherapy because of esophagitis. Conclusion (1) LAHF plus concurrent chemotherapy is tolerable, although its toxicity is more serious than CF plus concurrent chemotherapy; (2) The hematopoietic, gastriointestinal and pulmonary toxicities are not significantly different between LAHF group and CF group. |
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