| ZHAO Hong-guang,WANG Zhi-cheng,GONG Ping-sheng.Protective effect of egg-milk with MT on mice injured by X-irradiation[J].Chinese Journal of Radiological Medicine and Protection,2005,25(4):345-347 |
| Protective effect of egg-milk with MT on mice injured by X-irradiation |
| Received:December 23, 2004 |
| DOI： |
| KeyWords:Metallothionein (MT) Ionizing radiation Radiation protective effect |
| FundProject: |
| Author Name | Affiliation | E-mail | | ZHAO Hong-guang | MH Radiobiology Research Unit, School of Public Health, Jilin University, Changchun 130021, China | gongsl@163.com | | WANG Zhi-cheng | MH Radiobiology Research Unit, School of Public Health, Jilin University, Changchun 130021, China | | | GONG Ping-sheng | 吉林大学酶工程教育部重点实验室 | | | 刘淑春 | MH Radiobiology Research Unit, School of Public Health, Jilin University, Changchun 130021, China | | | 吕文天 | MH Radiobiology Research Unit, School of Public Health, Jilin University, Changchun 130021, China | | | 史经宇 | 哈尔滨春源生物科技开发有限公司 | | | 龚守良 | MH Radiobiology Research Unit, School of Public Health, Jilin University, Changchun 130021, China | |
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| Abstract:: |
| Objective To explore the protective effect of egg-milk with metallothionein (MT) on the mice injured by X-irradiation. Methods After fed intragastrically with egg-milk plus MT for 14 d, mice were irradiated with 2.5 Gy X-rays. Twenty-four hours after the mice were irradiated, the number of WBC in peripheral blood, lymphocyte proliferation rate, DNA content of marrow cells, thymocyte cycle progression, malondialdehyde (MDA) level and the activities of SOD, CAT, GSH-Px in liver, serum and kidney were measured. Results In irradiated mice fed with egg-milk plus MT, the WBC number, lymphocyte proliferation rate, DNA content of marrow cells, the activities of SOD, CAT and GSH-Px in liver, kidney and serum were all significantly higher than those in the irradiation alone group. Besides in the former group the MDA level decreased significantly, the G-1 phase arrest in thymocytes was weakened and DNA synthesis was promoted. Conclusion The egg-milk with MT has protective effect on the mice injured by X-irradiation. |
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