| TU Yu,ZHOU Ju-ying,WANG Li-li.Inhibitory effect of MgSO4 on calcium overload after radiation-induced brain injuries[J].Chinese Journal of Radiological Medicine and Protection,2005,25(4):339-341 |
| Inhibitory effect of MgSO4 on calcium overload after radiation-induced brain injuries |
| Received:October 29, 2004 |
| DOI： |
| KeyWords:Magnesium sulfate Brain Radiation effects Rats |
| FundProject:苏州大学优秀青年骨干教师培养人选科研基金项目 |
|
| Hits: 2639 |
| Download times: 1979 |
| Abstract:: |
| Objective To explore the neuroprotective effect of magnesium sulfate(MgSO4) on radiation-induced acute brain injuries. Methods A total of 60 mature Sprague-Dawley rats were randomly divided into 3 groups: blank control group, experimental control group and experimental therapy group. The whole brain of SD rats of experimental control group and experimental therapy group was irradiated to a dose of 20 Gy using 6 MeV electrons. Magnesium sulfate was injected intraperitoneally into the rats of experimental therapy group before and after irradiation for five times. At different time points (24 h, 7 days, 14 days, 30 days after irradiation), the brain tissue was taken. Plasma direct reading spectrography was used to measure the contents of Ca2+,Mg2+ in brain tissue, and the percentage of brain water content was calculated with the wet-dry weight formula. Results Compared with the blank control group, the percentage of brain water and content of Ca2+ in brain of the experimental control group increased markedly (P<0.05) while the level of Mg2+ decreased significantly (P<0.05). However, the percentagees of brain water and content of Ca2+ in brain of the experimental therapy group were significantly lower than those of the experimental control group (P<0.05). Conclusion Magnesium sulfate used in the early stage after irradiation can inhibit the calcium overload in rat brain, and attenuate brain edema and injuries.; |
| HTML View Full Text View/Add Comment Download reader |
| Close |
|
|
|
